Issels Immunotherapy for Cancer Treatment Components
Issels Immunotherapy for cancer is integrative and consists of specific and non-specific treatment components. The specific treatment components are directed at the cancer tumor itself and the non-specific treatment components are directed at the tumor microenvironment with its crucial role in disease progression or regression.
These specific and non-specific immune-enhancing components work with each other synergistically. Their effectiveness is enhanced through their integration into a treatment program that addresses the different levels of the body’s complex immune, regulatory, and defense functions.
Many years of extensive experience in cancer immunotherapy have taught the Issels doctors how to optimize the immune-boosting effect by integrating specific and non-specific treatment components into a treatment program and how to adjust them to each patient’s unique needs.
Specific Vaccine and Cell Therapy Protocols.
The Immunotherapy protocols administered at our in-patient facilities include autologous vaccine and cell therapies that are prepared from the patient’s “own immune system cells”, by evaluating and using their molecular profile. Hence, they are “individualized” and specific, which enhances their potency.
Dendritic Cell Cancer Vaccine for all types of cancer is prepared from the patients’ peripheral monocytes in vitro in the presence of a recombinant growth factor, special cytokines and their own tumor antigens to achieve a specific immune response. Dendritic cells are key regulators of immune responses and orchestrate innate and adaptive immunities. They are the most potent antigen-presenting cells and have the potential to invoke an anti-tumor immune response.
Dendritic Cell Prostate Cancer Vaccine is prepared from the patients’ peripheral monocytes in vitro in the presence of a recombinant growth factor, special cytokines and their own prostate-specific antigen, which is fractionated into peptides in order to achieve a more specific anti-tumor immune response.
Lymphokine-Activated Killer Cells, also known as LAK Cells are prepared from the patient’s lymphocytes that in the presence of Interleukin-2 are expanded and activated to kill cancer cells.
Activated Natural Killer Cells, also known as NK Cells are prepared from the patient’s natural killer cells, a type of lymphocytes of the innate immune system that in the presence of Interleukin-21 are expanded and activated to kill cancer cells.
Coley’s Mixed Bacterial Vaccine stimulates the formation of the body’s own interferons, interleukins, tumor necrosis factor and other potent disease fighters.
The specific vaccine and cell immunotherapies stimulate the cell-mediated immunity and are integrated into the Issels® immunobiologic core treatment, which is designed to rebuild and activate also the various other levels of the body’s very complex defense mechanisms.