Issels Integrative Immuno-Oncology August 16, 2018  

New Research: How to Starve Cancer Tumors Cells

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Cancer research is now going beyond the genetic aspect to explore how the disease interacts with the body's systems. Recent studies of the relationship between cancer and fat cells may have implications concerning immunotherapy for cancer.

Feeding the Growth of Cancer Cells

While the precise causes are not yet known, obesity has been identified as a risk factor for prostate cancer, which is the second leading cause of cancer-related deaths in men. As a result, research into the link between cancer and fat cells has focused on this form of the disease.

Previous tests involved mice who were fed a high-fat diet. In contrast, researchers at Sanford Prebys Medical Discovery Institute in San Diego conducted a study using mice who lacked a protein called p62, causing them to become obese on a normal diet.

According to co-author Dr. Jorge Moscat, this control was necessary to get a clear understanding of the communication pathways between cancer and fat cells. The team discovered that p62 suppresses another protein known as mTORC1, which in turn inhibits energy use by fat cells.

Can Cancer Cells Be "Starved" to Death?

With metabolism halted in fat cells, nutrients are then available to fuel development of tumor cells. Lack of p62 also triggers production of proteins found at high levels in particularly aggressive forms of prostate cancer.

As explained by Dr. Moscat, these findings can help identify specific substances to be targeted by treatments with the goal of "starving" cancer cells.

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New Research: How to Starve Cancer Tumors Cells

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High Fat Diets Are Linked To Colon Cancer

Researchers observed significant changes in the intestinal stem cells that cause cancer in the test mice:

• The mice eating a high-fat diet had a higher number of intestinal stem cells. In addition, they were able to operate free of input from niche cells that normally regulate stem cell activity.

• Progenitor cells, which are differentiated "daughters" of stem cells, began to take on characteristics of stem cells, including longer life span and ability to generate mini-intestines outside the body.

Researchers say with further investigation, this information may lead to identifying new methods of cancer treatment for obesity-related tumors.


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