Issels Integrative Immuno-Oncology January 11, 2018  

Tumor Heterogeneity: Why Some Cancers are Drug and Treatment Resistant

Dear Friend,

For decades, scientists have tried to uncover the mysteries behind the complex behaviors of cancer cells. Thanks to gene sequencing and other molecular diagnosis tools, they are beginning to understand the process behind metastasis and drug resistance.

Solving the Puzzles of Metastasis and Drug Resistance

Cancer treatment is sometimes hampered by two significant problems:

Metastasis, or stage IV cancer, occurs when cancer cells migrate from the original site to other parts of the body. Surgery is no longer an option at stage IV, which significantly reduces survival rates.

• Drug resistance sets in when treatment reaches a point where cancer cells are no longer vulnerable to attack and they resume spreading.

Scientists have discovered that cancer cells can vary greatly between the original site and metastatic site, and even within a single tumor. This characteristic is referred to as tumor heterogeneity.

How Does Tumor Heterogeneity Affect Cancer Treatment?

Research has uncovered significant evidence demonstrating that cancer cells continue to evolve.

Gene mutations can create a subset of cancer cells with the ability to break away from the original tumor site.

• Drugs that target specific cancer cells can lose effectiveness as the original mutations are lost.

Doctors are using this knowledge of tumor heterogeneity to prescribe combination therapies that attack multiple genetic and molecular targets.

Issels®: A Pioneer in Combination Therapies

Our individual immunotherapy programs are integrative, combining treatments that work together to form a comprehensive attack on cancer cells. Contact us to learn why Issels® is the right choice for powerful and non-toxic cancer treatment for patients in late and early stages.

Tumor Heterogeneity: Why Some Cancers are Drug and Treatment Resistant

Read more interesting articles on the "Issels Cancer Immunotherapy" news/blog posted every Tuesday and Thursday. Check It Out Now »

What Makes the Issels Immunotherapy Program So Different?

Issels® immunotherapy protocols boost your body's immune response to use the power of your own natural defense mechanisms. The Issels® immunotherapy treatment has no adverse side effects. Our immunotherapy is non-toxic and has less risk of side effects than traditional cancer treatments such as chemotherapy and radiation. Our immunotherapy programs should also be distinguished from pharmaceutically-developed immunotherapy drugs, which can trigger serious negative reactions.

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Targeting Cancer by Biomarker versus Cancer Location

In May 2017, after five clinical trials, the Federal Drug Administration (FDA) approved a medication for use in treating tumors with a particular biomarker, regardless of location. At this point, the new use of this new medication is limited to patients for whom other therapies have been unsuccessful.

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Videos – What Do Patients Say About Their Experience?

Watch videos of patients who share their own experiences at the Issels clinics with you. Listen to their stories and cancer journeys.

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