Issels Integrative Immuno-Oncology March 8, 2018  

Gut Bacteria Appears to Influences Cancer Tumor Progression

Dear Friend,

Bacteria is generally considered to be the cause of disease and infection, but many varieties have beneficial properties. Scientists are discovering that "good" bacteria living inside of us can have positive implications for cancer treatment.

How Can Bacteria Be "Good?"

The microbiome is a collection of microscopic organisms found inside our bodies, primarily in the gut. These organisms play a role in the digestive process and help to regulate the immune system.

Researchers in France and the United States conducted separate studies involving the microbiome of cancer patients. All participants were receiving immunotherapy treatment, which boosts the ability of the immune system to fight cancer cells.

The Relationship Between Gut Bacteria and Cancer Treatment

The team at the Gustave Roussy Cancer Campus in Paris studied 249 patients with lung or kidney cancer.

• Participants who had taken antibiotics, which disturb the microbiome, were more likely to experience tumor growth, even during treatment.

• A bacteria species known as A. muciniphila was found in two-thirds of patients who responded to immunotherapy, as opposed to only one-third of those who did not.

At the University of Texas MD Anderson Cancer Center, a team analyzed the microbiome of 112 patients with advanced melanoma.

• Patients who responded to cancer treatment were found to have a more rich and varied microbiome than those who didn't.

• The composition of the microbiome also appeared to be significant, as higher levels of certain bacteria were associated with positive responses while others had negative impacts.

Innovative Cancer Treatment at Issels®

Our immunotherapy programs focus on cancer cells as well as the internal environment that supports them. Contact us for more information today. Gut Bacteria Appears to Influences Cancer Tumor Progression

Read more interesting articles on the "Issels Cancer Immunotherapy" news/blog posted every Tuesday and Thursday. Check It Out Now »


Could This Bacterial Molecule Stimulate The Immune System To Fight Cancer?

The drug, known as G100, was based on a molecule called lipopolysaccharide that is carried within certain bacteria. Study participants received an injection of G100 directly into the tumor, along with a course of focused radiation. The injected tumors stopped growing, shrank or even disappeared in 14 of the 15 patients, while tumor growth throughout the body stopped in six of them.

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Is There A Link Between Gut Bacteria And An Immunotherapy Response?

While scientists had previously made the connection with mice, a team at the University of Texas MD Anderson Cancer Center recently made a breakthrough with the first study involving humans. The subjects included 233 patients with advanced melanoma. The researchers discovered that the 30 patients who responded had a wider variety of gut bacteria, particularly a specific type called Clostridiales, along with a higher concentration of the immune cells that fight cancer.

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Videos – What Do Patients Say About Their Experience?

Watch videos of patients who share their own experiences at the Issels clinics with you. Listen to their stories and cancer journeys.

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