{"id":2143,"date":"2015-09-03T03:00:53","date_gmt":"2015-09-03T08:00:53","guid":{"rendered":"https:\/\/issels.com\/blog\/?p=2143"},"modified":"2015-08-29T19:14:10","modified_gmt":"2015-08-30T00:14:10","slug":"doorway-in-blood-vessels-allows-breast-cancer-to-spread-via-the-blood","status":"publish","type":"post","link":"https:\/\/issels.com\/blog\/2015\/09\/03\/doorway-in-blood-vessels-allows-breast-cancer-to-spread-via-the-blood\/","title":{"rendered":"Doorway in Blood Vessels Allows Breast Cancer to Spread Via the Blood"},"content":{"rendered":"<figure id=\"attachment_71\" aria-describedby=\"caption-attachment-71\" style=\"width: 200px\" class=\"wp-caption alignright\"><a href=\"https:\/\/issels.com\/blog\/wp-content\/uploads\/2013\/03\/MP9003373501.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-71\" src=\"https:\/\/issels.com\/blog\/wp-content\/uploads\/2013\/03\/MP9003373501-214x300.jpg\" alt=\"Breast Cancer Awareness Ribbon\" width=\"200\" height=\"280\" srcset=\"https:\/\/issels.com\/blog\/wp-content\/uploads\/2013\/03\/MP9003373501-214x300.jpg 214w, https:\/\/issels.com\/blog\/wp-content\/uploads\/2013\/03\/MP9003373501.jpg 428w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><figcaption id=\"caption-attachment-71\" class=\"wp-caption-text\">Breast Cancer Can Be Spread Through The Blood<\/figcaption><\/figure>\n<p>What if you could literally <a href=\"http:\/\/www.cancerresearchuk.org\/about-us\/cancer-news\/news-report\/2015-08-11-researchers-find-doorway-in-blood-vessels-that-helps-breast-cancer-cells-spread-through-the-body\">close the door<\/a> on metastasizing cancer? A recent U.S. study has discovered this doorway, and <a href=\"http:\/\/issels.com\">Issels\u00ae<\/a> wants to let you in on the latest findings and how they might benefit your cancer treatment goals\u2026<\/p>\n<p><strong>Escape artists<\/strong><br \/>\nWhen three specific types of cells work together, cancer can escape into the blood stream. Their plan?<\/p>\n<ul>\n<li><strong><em>Cancer cells<\/em><\/strong> near blood vessels interact with <strong><em>macrophages<\/em><\/strong>, a type of white blood cell.<\/li>\n<\/ul>\n<ul>\n<li>The macrophages release a protein, called vascular endothelial growth factor (VEGF), which increases the permeability or leakiness of <strong><em>endothelial cells<\/em><\/strong> in the blood vessel wall.<\/li>\n<\/ul>\n<ul>\n<li>A doorway is temporarily created, through which cancer cells escape and spread into the bloodstream.<\/li>\n<\/ul>\n<p><strong>The right environment<\/strong><br \/>\nPreviously, what regulated the permeability of blood vessel walls at the escape site wasn\u2019t clear. However thanks to the new imaging studies, the mechanism has been identified: macrophages at the tumor microenvironment of metastasis (TMEM), or TMEM macrophages.<\/p>\n<p><strong>Closing the door<\/strong><br \/>\nWhile the\u00a0VGEF\u00a0protein produced by macrophages in the aforementioned escape process is\u00a0already\u00a0the target of\u00a0existing cancer drugs, the recent study shows how this leakiness \u2013 cancer\u2019s escape hatch &#8211; can be switched on and off by TMEM macrophages \u2013 the specific immune cells playing accomplice to the great escape.<\/p>\n<p><strong>A new frontier<\/strong><br \/>\nThe work performed on mice and building on previous findings from the Albert Einstein Cancer Center and Montefiore Einstein Center for Cancer Care, could lead to new drugs for preventing the spread of cancer.<\/p>\n<p>Are your ready to close the door on cancer treatment? Kick cancer out for good and throw away the key with the help of <a href=\"http:\/\/issels.com\">Issels\u00ae <\/a>today!<\/p>\n","protected":false},"excerpt":{"rendered":"<p>What if you could literally close the door on metastasizing cancer? A recent U.S. study has discovered this doorway, and Issels\u00ae wants to let you in on the latest findings and how they might benefit your cancer treatment goals\u2026 Escape artists When three specific types of cells work together, cancer can escape into the blood &hellip; <a href=\"https:\/\/issels.com\/blog\/2015\/09\/03\/doorway-in-blood-vessels-allows-breast-cancer-to-spread-via-the-blood\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Doorway in Blood Vessels Allows Breast Cancer to Spread Via the Blood<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[202,203,204],"tags":[243,259],"class_list":["post-2143","post","type-post","status-publish","format-standard","hentry","category-alternative-cancer-treatment","category-cancer-research","category-living-with-cancer","tag-breast-cancer","tag-fighting-cancer"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/2143","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/comments?post=2143"}],"version-history":[{"count":1,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/2143\/revisions"}],"predecessor-version":[{"id":2144,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/2143\/revisions\/2144"}],"wp:attachment":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media?parent=2143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/categories?post=2143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/tags?post=2143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}