{"id":2531,"date":"2016-11-15T03:00:46","date_gmt":"2016-11-15T08:00:46","guid":{"rendered":"https:\/\/issels.com\/blog\/?p=2531"},"modified":"2016-11-02T13:48:58","modified_gmt":"2016-11-02T18:48:58","slug":"off-label-drug-use-rises-in-fight-against-cancer","status":"publish","type":"post","link":"https:\/\/issels.com\/blog\/2016\/11\/15\/off-label-drug-use-rises-in-fight-against-cancer\/","title":{"rendered":"Off Label Drug Use Rises in Fight against Cancer"},"content":{"rendered":"<figure id=\"attachment_2532\" aria-describedby=\"caption-attachment-2532\" style=\"width: 200px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2532\" src=\"https:\/\/issels.com\/blog\/wp-content\/uploads\/2016\/11\/Depositphotos_27130631_s-2015-350x227.jpg\" alt=\"Repurpasing Cancer Drugs\" width=\"200\" height=\"130\" srcset=\"https:\/\/issels.com\/blog\/wp-content\/uploads\/2016\/11\/Depositphotos_27130631_s-2015-350x227.jpg 350w, https:\/\/issels.com\/blog\/wp-content\/uploads\/2016\/11\/Depositphotos_27130631_s-2015.jpg 500w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><figcaption id=\"caption-attachment-2532\" class=\"wp-caption-text\">Repurposing Cancer Drugs<\/figcaption><\/figure>\n<p>In recent years, drug repositioning or repurposing has become a valuable strategy in <a href=\"http:\/\/issels.com\/\">immunotherapy for cancer<\/a> as researchers find previously <a href=\"https:\/\/www.sciencedaily.com\/releases\/2016\/09\/160929082026.htm\">unknown uses for approved drugs<\/a>.<\/p>\n<p><strong>&#8220;Multitasking&#8221; Drugs<\/strong><\/p>\n<p>A research team at the University of Bergen in Norway has been searching for chemical compounds that can shut down a tumor&#8217;s signaling system, preventing continued growth and spread. Over a five-year period, the researchers scanned thousands of compounds ranging from Chinese herbs to FDA-approved drugs.<\/p>\n<p>While testing current drugs, the team discovered that axitinib, a drug used on kidney cancer, has properties that knock out communication paths between <a href=\"https:\/\/issels.com\/blog\/2016\/07\/26\/higher-genetic-mistakes-in-tumors-may-predict-a-better-result-for-immunotherapy-treatment\/\">mutant cells<\/a>. Since 90 percent of all cancers are caused by mutations, researchers are hopeful that the drug can be put to use on breast, prostate, colorectal and other forms of cancer.<\/p>\n<p><strong>A New Direction for Cancer Treatment<\/strong><\/p>\n<p>With the development of new pharmaceuticals taking up to 10 years, repurposing has become a popular cost- and time-effective strategy. The University of Bergen team has also identified a handful of other promising compounds for testing. Lead Professor Karl-Henning Kalland believes that axitinib holds strong potential for use in combination with <a href=\"http:\/\/issels.com\/treatment-summary\/\">immunotherapy for cancer<\/a>.<\/p>\n<p><strong>Issels\u00ae Is on the Cutting Edge of Immunotherapy for Cancer<\/strong><\/p>\n<p>Whether it&#8217;s repurposing drugs, cancer vaccines or NK cells, you can be sure that Issels\u00ae will be a leader in the use of personally developed, non-toxic immunotherapy treatments. <a href=\"http:\/\/66.135.32.155\/issels\/Questionnaire\/request-issels-info.aspx\">Contact us<\/a> to read and hear real-life testimonials from patients with all forms of cancer, including lung, melanoma and leukemia, which have been successfully treated at Issels\u00ae.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In recent years, drug repositioning or repurposing has become a valuable strategy in immunotherapy for cancer as researchers find previously unknown uses for approved drugs. &#8220;Multitasking&#8221; Drugs A research team at the University of Bergen in Norway has been searching for chemical compounds that can shut down a tumor&#8217;s signaling system, preventing continued growth and &hellip; <a href=\"https:\/\/issels.com\/blog\/2016\/11\/15\/off-label-drug-use-rises-in-fight-against-cancer\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Off Label Drug Use Rises in Fight against Cancer<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[202,473,203,216],"tags":[222,553,259],"class_list":["post-2531","post","type-post","status-publish","format-standard","hentry","category-alternative-cancer-treatment","category-breast-cancer","category-cancer-research","category-immunotherapy","tag-advanced-cancer-research","tag-cancer-drugs","tag-fighting-cancer"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/2531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/comments?post=2531"}],"version-history":[{"count":1,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/2531\/revisions"}],"predecessor-version":[{"id":2533,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/2531\/revisions\/2533"}],"wp:attachment":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media?parent=2531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/categories?post=2531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/tags?post=2531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}