{"id":2609,"date":"2017-02-02T03:00:04","date_gmt":"2017-02-02T08:00:04","guid":{"rendered":"https:\/\/issels.com\/blog\/?p=2609"},"modified":"2017-01-19T10:33:20","modified_gmt":"2017-01-19T15:33:20","slug":"brain-tumors-greed-for-cholesterol-may-create-a-treatment-opportunity","status":"publish","type":"post","link":"https:\/\/issels.com\/blog\/2017\/02\/02\/brain-tumors-greed-for-cholesterol-may-create-a-treatment-opportunity\/","title":{"rendered":"Brain Tumor’s Greed for Cholesterol May Create a Treatment Opportunity"},"content":{"rendered":"
\"A
Fight Brain Cancer With Cholesterol<\/figcaption><\/figure>\n

When it comes to fitness and nutrition, cholesterol has become a bad word. But a team of researchers has discovered that the substance may turn out to be a surprising hero in the <\/span>fight against cancer<\/span><\/a>.<\/span><\/p>\n

Brain Cancer Treatment Hits a Dead End<\/span><\/strong><\/p>\n

Details of the study, conducted jointly by Ludwig Cancer Research San Diego and Scripps, were published last fall in Cancer Cell<\/em>. The project involved <\/span>glioblastoma (GBM)<\/span><\/a>, an aggressive and incurable form of brain cancer.<\/span><\/p>\n

The scientific community had reached an impasse in the treatment of GBM. Although the cancer cells had been extensively studied, <\/span>targeted therapies<\/span><\/a> based on these analyses proved ineffective and served only to increase the tumor’s drug resistance.<\/span><\/p>\n

Hope Comes from an Unlikely Source<\/span><\/strong><\/p>\n

The research team found clues in the way brain cells process cholesterol. The brain actually manufactures its own cholesterol, and when the cells have enough a receptor is activated that starts releasing the excess.<\/span><\/p>\n

In contrast, GBM cells crave large amounts of cholesterol but do not manufacture it. Their shut-off receptor remains inactive, allowing them to “steal” cholesterol from normal cells and use it to grow.<\/span><\/p>\n

Researchers implanted GBM tumors from humans into mice and treated them with a drug that triggers the shut-off receptor. As a result, many of the cancer cells were destroyed, causing significant shrinkage in the tumors and extending the lives of the affected mice.<\/span><\/p>\n

Immunotherapy for Cancer: Treatment for All Forms of Tumors<\/span><\/strong><\/p>\n

Our non-toxic, personally developed <\/span>immunotherapy for cancer<\/span><\/a> programs at Issels\u00ae have helped patients with all forms of cancer, from melanoma and lymphoma to breast and lung cancer. <\/span>Contact us<\/span><\/a> for more information.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

When it comes to fitness and nutrition, cholesterol has become a bad word. But a team of researchers has discovered that the substance may turn out to be a surprising hero in the fight against cancer. Brain Cancer Treatment Hits a Dead End Details of the study, conducted jointly by Ludwig Cancer Research San Diego … Continue reading Brain Tumor’s Greed for Cholesterol May Create a Treatment Opportunity<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[202,203],"tags":[411,259],"class_list":["post-2609","post","type-post","status-publish","format-standard","hentry","category-alternative-cancer-treatment","category-cancer-research","tag-brain-cancer","tag-fighting-cancer"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/2609","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/comments?post=2609"}],"version-history":[{"count":1,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/2609\/revisions"}],"predecessor-version":[{"id":2610,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/2609\/revisions\/2610"}],"wp:attachment":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media?parent=2609"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/categories?post=2609"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/tags?post=2609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}