{"id":2615,"date":"2017-02-09T03:00:09","date_gmt":"2017-02-09T08:00:09","guid":{"rendered":"https:\/\/issels.com\/blog\/?p=2615"},"modified":"2017-01-21T16:16:13","modified_gmt":"2017-01-21T21:16:13","slug":"strategic-t-cells-use-may-be-the-key-to-effective-cancer-treatment","status":"publish","type":"post","link":"https:\/\/issels.com\/blog\/2017\/02\/09\/strategic-t-cells-use-may-be-the-key-to-effective-cancer-treatment\/","title":{"rendered":"Strategic T Cells Use May Be the Key to Effective Cancer Treatment"},"content":{"rendered":"
\"\"
Advanced T Cells<\/figcaption><\/figure>\n

T cells are the warriors of your immune system, but the ongoing battle against cancer can sap them of their disease-fighting powers. New research has discovered crucial information about these “exhausted” cells that can lead to more powerful <\/span>immunotherapy for cancer<\/span><\/a>.<\/span><\/p>\n

The fundamental difference between <\/span>active and exhausted T cells<\/span><\/a> lies in their gene patterns. One example is PD-1, a protein expressed by exhausted T cells that prevents them from attacking both healthy and diseased cells. Checkpoint inhibitors can block PD-1, but their use is productive in only 25 percent of cases.<\/span><\/p>\n

Can “Exhausted” T Cells Be Revived?<\/span><\/strong><\/p>\n

According to Nicholas Haining of Dana-Farber\/Boston Children’s, senior author of the report posted in the journal Science<\/em>, the goal of the study was to determine whether exhausted T cells are simply run-down versions of functional T cells or a separate type entirely. Regulatory regions of T cell genomes were mapped using chronically infected mice as subjects.<\/span><\/p>\n

Results showed that the two types of cells are controlled by completely different wiring. In a separate study, use of <\/span>checkpoint inhibitors<\/span><\/a> gave the exhausted T cells a temporary boost, but did nothing to convert them to an active state.<\/span><\/p>\n

The researchers hope this information will help to improve CAR T-cell therapy, in which <\/span>T cells<\/span><\/a> are removed from a patient and retrofitted to attack tumor cells. Complete mapping of regulatory regions will provide more precise targets for treatment.<\/span><\/p>\n

Immunotherapy for Cancer Focuses on Tumors and Their Causes<\/span><\/strong><\/p>\n

At Issels\u00ae, our <\/span>integrative programs<\/span><\/a> are aimed at eliminating cancer cells and enhancing your body’s own natural defense mechanisms. <\/span>Contact us today<\/span><\/a> for more information.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

T cells are the warriors of your immune system, but the ongoing battle against cancer can sap them of their disease-fighting powers. New research has discovered crucial information about these “exhausted” cells that can lead to more powerful immunotherapy for cancer. The fundamental difference between active and exhausted T cells lies in their gene patterns. … Continue reading Strategic T Cells Use May Be the Key to Effective Cancer Treatment<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[202,203,216],"tags":[222,259,574],"class_list":["post-2615","post","type-post","status-publish","format-standard","hentry","category-alternative-cancer-treatment","category-cancer-research","category-immunotherapy","tag-advanced-cancer-research","tag-fighting-cancer","tag-t-cell-treatment"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/2615","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/comments?post=2615"}],"version-history":[{"count":1,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/2615\/revisions"}],"predecessor-version":[{"id":2616,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/2615\/revisions\/2616"}],"wp:attachment":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media?parent=2615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/categories?post=2615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/tags?post=2615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}