{"id":2924,"date":"2017-10-11T02:53:22","date_gmt":"2017-10-11T07:53:22","guid":{"rendered":"https:\/\/issels.com\/blog\/?p=2924"},"modified":"2017-09-23T18:59:25","modified_gmt":"2017-09-23T23:59:25","slug":"new-biomarker-may-predict-the-bodys-response-to-chemotherapy-and-radiation","status":"publish","type":"post","link":"https:\/\/issels.com\/blog\/2017\/10\/11\/new-biomarker-may-predict-the-bodys-response-to-chemotherapy-and-radiation\/","title":{"rendered":"New Biomarker May Predict the Body’s Response to Chemotherapy and Radiation"},"content":{"rendered":"
\"There
There is New Hope for Cancer Patients. Don’t Give up!<\/figcaption><\/figure>\n

One of the difficulties doctors have in prescribing cancer treatment<\/a> is knowing which methods will be most effective. That may change with the discovery of a biomarker that may help predict a tumor’s response<\/a> to chemotherapy and radiation.<\/p>\n

How Cell Division Affects Cancer Development<\/strong><\/p>\n

When cells divide, the duplicated chromosomes are pulled apart into the two new cells. A malfunction in this process can lead to chromosomal instability, which has the potential to drive development of cancer cells.<\/p>\n

Researchers set out to study the expression of genes associated with normal chromosome division<\/a>. Specifically, they wanted to find out how genetic changes contribute to chromosomal instability and whether these changes held clues regarding the behavior of tumors.<\/p>\n

Genetic Markers of Chromosomal Instability<\/strong><\/p>\n

The team from Lawrence Berkeley National Laboratory examined 31 genes that had previously been identified as part of the chromosome division process. They discovered that these genes were over- or under-expressed in different types of cancer as opposed to corresponding normal tissue samples.<\/p>\n

This led to the development of a 14-gene subset named the Centromere and kinetochore gene Expression Score, or CES. When measuring CES in tumor sample databases, the researchers found that a high score correlated with elevated levels of chromosomal instability.<\/p>\n

Based on these encouraging results, researchers are hopeful that the biomarker can be used to predict response to cancer treatment<\/a> as well as prognosis with or without treatment.<\/p>\n

Immunotherapy: An Integrative Approach to Cancer Treatment<\/strong><\/p>\n

Immunotherapy at Issels\u00ae doesn’t carry the risk of debilitating side effects<\/a> that accompanies traditional cancer treatments. Contact us<\/a> for more information.<\/p>\n","protected":false},"excerpt":{"rendered":"

One of the difficulties doctors have in prescribing cancer treatment is knowing which methods will be most effective. That may change with the discovery of a biomarker that may help predict a tumor’s response to chemotherapy and radiation. How Cell Division Affects Cancer Development When cells divide, the duplicated chromosomes are pulled apart into the … Continue reading New Biomarker May Predict the Body’s Response to Chemotherapy and Radiation<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[202,203,205,216,538],"tags":[625,611,212,238,626],"class_list":["post-2924","post","type-post","status-publish","format-standard","hentry","category-alternative-cancer-treatment","category-cancer-research","category-immuno-oncology","category-immunotherapy","category-immunotherapy-for-cancer","tag-biomarkers-for-cancer","tag-cancer-biomarkers","tag-cancer-research","tag-links-to-cancer","tag-markers-for-cancer"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/2924","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/comments?post=2924"}],"version-history":[{"count":2,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/2924\/revisions"}],"predecessor-version":[{"id":2938,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/2924\/revisions\/2938"}],"wp:attachment":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media?parent=2924"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/categories?post=2924"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/tags?post=2924"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}