{"id":3075,"date":"2018-01-03T03:03:25","date_gmt":"2018-01-03T08:03:25","guid":{"rendered":"https:\/\/issels.com\/blog\/?p=3075"},"modified":"2017-12-28T00:06:58","modified_gmt":"2017-12-28T05:06:58","slug":"tumor-suppressing-protein-may-lead-to-new-pancreatic-cancer-treatments","status":"publish","type":"post","link":"https:\/\/issels.com\/blog\/2018\/01\/03\/tumor-suppressing-protein-may-lead-to-new-pancreatic-cancer-treatments\/","title":{"rendered":"Tumor Suppressing Protein May Lead to New Pancreatic Cancer Treatments"},"content":{"rendered":"
\"Tumor
Tumor Suppressing Protein May Lead to New Pancreatic Cancer Treatments<\/figcaption><\/figure>\n

While a protein known as p53<\/a> has long been recognized as a potent factor in suppressing tumors, the reasons have been unclear. Scientists are now discovering more about p53, including the existence of a “super” version, that may have valuable implications for cancer immunotherapy<\/a>.<\/p>\n

Finding the Right Balance<\/strong><\/p>\n

Balance is essential for realizing the maximum benefits of p53. Too little leaves the door open for tumor growth, but too much can cause developmental problems.<\/p>\n

A research team at the Stanford University School of Medicine tested a variety of p53 mutations on mice that were susceptible to pancreatic cancer<\/a>. The scientists were surprised to find that one version of the protein kept the mice tumor-free for longer periods of time.<\/p>\n

A “Supercharged” Tumor Suppressor<\/strong><\/p>\n

According to Dr. Laura Attardi, senior author of the study, the mutated protein hit a “sweet spot” that allowed embryos to develop without any problems and gave adult mice greater resistance to tumors. The mutation appears to hyperactivate the p53 protein, causing it to affect a number of downstream targets.<\/p>\n

With hundreds of genes impacted by p53 activity, Attardi’s team turned to the question of discovering which ones were involved in tumor development<\/a>. They discovered the pathway of three proteins, led by p53, that created a chain reaction preventing development of tumor cells.<\/p>\n

Issels\u00ae: Leading the Way in Cancer Immunotherapy<\/strong><\/p>\n

Our personalized immunotherapy programs<\/a> include gene-targeted therapies that shut down specific molecules required for cancer growth. Treatments are integrated with other therapies that combine for the most effective ways of fighting tumor cells.<\/p>\n

Contact us<\/a> to learn more about our success in helping patients achieve long-term remission<\/p>\n","protected":false},"excerpt":{"rendered":"

While a protein known as p53 has long been recognized as a potent factor in suppressing tumors, the reasons have been unclear. Scientists are now discovering more about p53, including the existence of a “super” version, that may have valuable implications for cancer immunotherapy. Finding the Right Balance Balance is essential for realizing the maximum … Continue reading Tumor Suppressing Protein May Lead to New Pancreatic Cancer Treatments<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[202,203,580,216,538,1],"tags":[282,252,327,631,358,471],"class_list":["post-3075","post","type-post","status-publish","format-standard","hentry","category-alternative-cancer-treatment","category-cancer-research","category-cancer-treatment","category-immunotherapy","category-immunotherapy-for-cancer","category-uncategorized","tag-cancer-news","tag-cancer-research-advancement","tag-gene-therapy","tag-new-approaches-to-cancer-treatment","tag-pancreatic-cancer","tag-tumor-protein"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3075","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/comments?post=3075"}],"version-history":[{"count":2,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3075\/revisions"}],"predecessor-version":[{"id":3086,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3075\/revisions\/3086"}],"wp:attachment":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media?parent=3075"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/categories?post=3075"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/tags?post=3075"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}