{"id":3130,"date":"2018-02-12T03:03:13","date_gmt":"2018-02-12T08:03:13","guid":{"rendered":"https:\/\/issels.com\/blog\/?p=3130"},"modified":"2018-01-30T16:06:53","modified_gmt":"2018-01-30T21:06:53","slug":"cancer-therapies-at-the-molecular-level-in-intracellular-proteins","status":"publish","type":"post","link":"https:\/\/issels.com\/blog\/2018\/02\/12\/cancer-therapies-at-the-molecular-level-in-intracellular-proteins\/","title":{"rendered":"Cancer Therapies at the Molecular Level in Intracellular Proteins"},"content":{"rendered":"
\"Cancer
Cancer Therapies at the Molecular Level in Intracellular Proteins<\/figcaption><\/figure>\n

As scientists work to refine immunotherapy cancer treatment<\/a>, they also look for ways to determine which patients are most likely to respond. According to a recent study, one of the answers may lie within a patient’s genetics<\/a>.<\/p>\n

HLA Molecules and Intracellular Proteins<\/strong><\/p>\n

T-cells are a type of white blood cell that’s part of the immune system. Human leukocyte antigen (HLA) molecules help direct T-cells towards cancer cells by binding peptides from intracellular proteins, including those found on tumor cells.<\/p>\n

Some immunotherapy treatments that have been successful in fighting metastatic cancers<\/a> focus on promoting activity of HLA-1 molecules. A research team at Memorial Sloan Kettering Cancer Center genotyped more than 1,500 advanced cancer patients to determine if HLA variants had an effect on post-treatment survival.<\/p>\n

Do HLA Variants Affect Cancer Treatment?<\/strong><\/p>\n

Since HLA-1 molecules come in a number of different forms with several variants, the researchers speculated that those variations would influence the patients’ responses to treatment. As expected, patients with greater diversity in HLA-1 molecules had a corresponding increase in survival rates.<\/p>\n

The study also considered the correlation between somatic mutations within a cancer genome<\/a> and HLA-1 variations. A higher tumor mutation burden in combination with more diverse HLA-1 molecules was linked to higher survival rates as well.<\/p>\n

Gene-Targeted Cancer Treatment at Issels\u00ae<\/strong><\/p>\n

Advanced gene-targeted therapies<\/a> are just one of the treatments available for our comprehensive and individually tailored programs. Non-toxic gene-targeted therapies attack only cancerous cells, making them less harmful to healthy tissues.<\/p>\n

Contact us<\/a> to learn more about cancer vaccines, NK cells and other treatment programs offered at Issels\u00ae.<\/p>\n","protected":false},"excerpt":{"rendered":"

As scientists work to refine immunotherapy cancer treatment, they also look for ways to determine which patients are most likely to respond. According to a recent study, one of the answers may lie within a patient’s genetics. HLA Molecules and Intracellular Proteins T-cells are a type of white blood cell that’s part of the immune … Continue reading Cancer Therapies at the Molecular Level in Intracellular Proteins<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[203,205,216,538,1],"tags":[539,452,442],"class_list":["post-3130","post","type-post","status-publish","format-standard","hentry","category-cancer-research","category-immuno-oncology","category-immunotherapy","category-immunotherapy-for-cancer","category-uncategorized","tag-cancer-immunotherapy","tag-immunotherapy-drugs","tag-new-cancer-research-methods"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3130","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/comments?post=3130"}],"version-history":[{"count":2,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3130\/revisions"}],"predecessor-version":[{"id":3132,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3130\/revisions\/3132"}],"wp:attachment":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media?parent=3130"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/categories?post=3130"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/tags?post=3130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}