{"id":3276,"date":"2018-05-21T03:29:24","date_gmt":"2018-05-21T08:29:24","guid":{"rendered":"https:\/\/issels.com\/blog\/?p=3276"},"modified":"2018-04-29T13:32:55","modified_gmt":"2018-04-29T18:32:55","slug":"ucla-research-shows-chimeric-antigen-receptors-may-boost-immune-system-response-to-fight-cancer","status":"publish","type":"post","link":"https:\/\/issels.com\/blog\/2018\/05\/21\/ucla-research-shows-chimeric-antigen-receptors-may-boost-immune-system-response-to-fight-cancer\/","title":{"rendered":"UCLA Research Shows Chimeric Antigen Receptors May Boost Immune System Response to Fight Cancer"},"content":{"rendered":"
\"UCLA
UCLA Research Shows Chimeric Antigen Receptors May Boost Immune System Response to Fight Cancer<\/figcaption><\/figure>\n

Tumors have a number of ways to avoid detection and attack by the body’s immune system, making them difficult to eliminate. In a victory for cancer immunotherapy<\/a>, scientists have created a synthetic protein<\/a> with the ability to reverse these defenses.<\/p>\n

Overcoming Safeguards of Tumor Cells<\/strong><\/p>\n

Most diseased cells carry proteins called antigens that trigger a response from T cells in the immune system, resulting in neutralization of the threat. In contrast, tumor cells secrete immunosuppressive cytokines, and these soluble proteins disable the immune response from T cells.<\/p>\n

Chimeric antigen receptor (CAR) T-cell therapy<\/a>, which received FDA approval in 2017, has been successfully used to treat blood cancers such as leukemia. Unfortunately, these therapies have not had a similar effect on solid tumors.<\/p>\n

Making Cancer Work Against Itself<\/strong><\/p>\n

Building on the principle of CARs and their power to counteract the defenses of cancer cells, a team of scientists at UCLA engineered CARs to respond to soluble proteins along with surface-bound antigens. In effect, cancer’s primary weapon ends up acting as an instrument of its own destruction.<\/p>\n

Since these CARs are engineered, it opens up the possibility of using this method to create cancer immunotherapy treatments<\/a> for other applications. The UCLA team has already engineered CARs that respond to various soluble proteins, including transforming growth factor (TGF) beta.<\/p>\n

Cancer Immunotherapy: Boosting the Body’s Own Immune System<\/strong><\/p>\n

Our individually developed immunotherapy programs<\/a> focus on restoring the body’s immune system and its natural defense mechanisms. These programs are non-toxic, without the adverse side effects that often accompany chemotherapy and other traditional cancer treatments.<\/p>\n

Visit our website<\/a> for more information.<\/p>\n","protected":false},"excerpt":{"rendered":"

Tumors have a number of ways to avoid detection and attack by the body’s immune system, making them difficult to eliminate. In a victory for cancer immunotherapy, scientists have created a synthetic protein with the ability to reverse these defenses. Overcoming Safeguards of Tumor Cells Most diseased cells carry proteins called antigens that trigger a … Continue reading UCLA Research Shows Chimeric Antigen Receptors May Boost Immune System Response to Fight Cancer<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[202,203,580,205,216,538,2],"tags":[695,539,696,307,471],"class_list":["post-3276","post","type-post","status-publish","format-standard","hentry","category-alternative-cancer-treatment","category-cancer-research","category-cancer-treatment","category-immuno-oncology","category-immunotherapy","category-immunotherapy-for-cancer","category-news","tag-antigens-receptors","tag-cancer-immunotherapy","tag-cytokines","tag-immune-therapies","tag-tumor-protein"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/comments?post=3276"}],"version-history":[{"count":2,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3276\/revisions"}],"predecessor-version":[{"id":3285,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3276\/revisions\/3285"}],"wp:attachment":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media?parent=3276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/categories?post=3276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/tags?post=3276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}