{"id":3280,"date":"2018-05-23T03:42:51","date_gmt":"2018-05-23T08:42:51","guid":{"rendered":"https:\/\/issels.com\/blog\/?p=3280"},"modified":"2018-04-29T13:47:50","modified_gmt":"2018-04-29T18:47:50","slug":"coleys-toxin-the-first-immunotherapy","status":"publish","type":"post","link":"https:\/\/issels.com\/blog\/2018\/05\/23\/coleys-toxin-the-first-immunotherapy\/","title":{"rendered":"Coley’s Toxin – the First Immunotherapy?"},"content":{"rendered":"
\"Coley's
Coley’s Toxin – the First Immunotherapy?<\/figcaption><\/figure>\n

When it comes to cancer treatment<\/a>, immunotherapy is a hot buzzword right now, but it may not be as new as it seems. Many scientists believe that the first immunotherapy treatments<\/a> date back to the late 1800s.<\/p>\n

Coley’s Toxins: The Original Immunotherapy?<\/strong><\/p>\n

William Coley, a surgeon in turn-of-the-century New York, made a peculiar discovery about one of his patients. Fred Stein, who had been diagnosed with cancer, began making a recovery after contracting a serious infection.<\/p>\n

Dr. Coley thought that perhaps bacteria from the infection jump-started Stein’s immune system, causing it to attack the tumors. This experience inspired the doctor to begin treating inoperable cancer patients with bacterial injections<\/a> that came to be known as Coley’s toxins.<\/p>\n

While Coley’s treatments did achieve some success, there was little documentation to support his findings. As a result, the doctor’s peers continued to favor radiation and chemotherapy as cancer treatments of choice.<\/p>\n

A Man Ahead of His Time<\/strong><\/p>\n

For all intents and purposes, Dr. Coley’s methods died with him in 1936. Now, more than 80 years later, immunotherapy cancer treatment<\/a> is “here to stay,” according to Jill O’Donnell-Tormey, chief executive of the Cancer Research Institute.<\/p>\n

Immunotherapies known as checkpoint inhibitors<\/a> are some of the top-selling drugs around the world. Checkpoint inhibitors follow Dr. Coley’s principle of boosting the body’s own immune response.<\/p>\n

Dr. Josef M. Issels: A Pioneer of Immunotherapy<\/strong><\/p>\n

We’re proud to carry on the legacy of our founder, Dr. Josef M. Issels<\/a>, who was also an early proponent of immunotherapy cancer treatment. Contact Issels\u00ae<\/a> for more information about our individually created immunotherapy programs.<\/p>\n","protected":false},"excerpt":{"rendered":"

When it comes to cancer treatment, immunotherapy is a hot buzzword right now, but it may not be as new as it seems. Many scientists believe that the first immunotherapy treatments date back to the late 1800s. Coley’s Toxins: The Original Immunotherapy? William Coley, a surgeon in turn-of-the-century New York, made a peculiar discovery about … Continue reading Coley’s Toxin – the First Immunotherapy?<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[202,203,205,216,538,2],"tags":[588,539,509,531,620,514],"class_list":["post-3280","post","type-post","status-publish","format-standard","hentry","category-alternative-cancer-treatment","category-cancer-research","category-immuno-oncology","category-immunotherapy","category-immunotherapy-for-cancer","category-news","tag-bacteria-and-cancer","tag-cancer-immunotherapy","tag-immuno-oncology","tag-immunotherapy-for-cancer","tag-immunotherapy-treatment","tag-integrative-immunotherapy"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3280","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/comments?post=3280"}],"version-history":[{"count":2,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3280\/revisions"}],"predecessor-version":[{"id":3287,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3280\/revisions\/3287"}],"wp:attachment":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media?parent=3280"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/categories?post=3280"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/tags?post=3280"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}