{"id":3393,"date":"2018-08-08T01:25:53","date_gmt":"2018-08-08T06:25:53","guid":{"rendered":"https:\/\/issels.com\/blog\/?p=3393"},"modified":"2018-08-03T07:18:28","modified_gmt":"2018-08-03T12:18:28","slug":"identification-of-key-biological-pathway-primes-immune-system-to-fight-cancer","status":"publish","type":"post","link":"https:\/\/issels.com\/blog\/2018\/08\/08\/identification-of-key-biological-pathway-primes-immune-system-to-fight-cancer\/","title":{"rendered":"Identification of Key Biological Pathway Primes Immune System to Fight Cancer"},"content":{"rendered":"
\"It's
It’s Time to Stop Cancer<\/figcaption><\/figure>\n

While immunotherapy cancer treatment<\/a> has provided options for many patients, doctors are challenged by determining which patients will be most receptive. The recent discovery of a key biological pathway<\/a> may prove to be a useful solution.<\/p>\n

Stimulating the Power of the Immune System<\/strong><\/p>\n

Cancer cells often avoid the normal immune response by triggering the brake mechanism that keeps T cells from attacking healthy tissue. Immunotherapy drugs called checkpoint inhibitors<\/a> override the brakes, but so far this treatment has been successful with a minority of patients.<\/p>\n

In 2014, a research team at UC San Francisco discovered an element of the immune system called stimulatory dendritic cells (SDC), which help direct T cells to a target. The scientists also uncovered a correlation between low levels of SDCs and poor response to checkpoint inhibitors.<\/p>\n

Creating a Receptive Environment for Immunotherapy <\/strong><\/p>\n

The team recently set out to learn why SDC levels vary among tumors. In this study, they found that natural killer (NK) cells<\/a> in the immune system express a signaling protein known as FLT3LG. Presence of FLT3LG has a strong relationship to presence of SDCs.<\/p>\n

While NK cells have long been recognized as a direct threat to cancer cells, the UCSF study demonstrates that they can also communicate with other immune cells. Scientists are hopeful that developing a way to increase the number of NK cells in a tumor will help more patients benefit from immunotherapy.<\/p>\n

Issels\u00ae: The Leader in Advanced Cancer Treatment<\/strong><\/p>\n

Issels\u00ae has been ahead of the curve with cancer treatment methods such as dendritic cell vaccines<\/a> and activated NK cells. Contact us<\/a> for more information.<\/p>\n","protected":false},"excerpt":{"rendered":"

While immunotherapy cancer treatment has provided options for many patients, doctors are challenged by determining which patients will be most receptive. The recent discovery of a key biological pathway may prove to be a useful solution. Stimulating the Power of the Immune System Cancer cells often avoid the normal immune response by triggering the brake … Continue reading Identification of Key Biological Pathway Primes Immune System to Fight Cancer<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[202,537,205,216,538,1],"tags":[224,219,615],"class_list":["post-3393","post","type-post","status-publish","format-standard","hentry","category-alternative-cancer-treatment","category-cancer-vaccine","category-immuno-oncology","category-immunotherapy","category-immunotherapy-for-cancer","category-uncategorized","tag-cancer-treatment","tag-immunotherapy","tag-immunotherapy-for-cancer-treatment"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/comments?post=3393"}],"version-history":[{"count":2,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3393\/revisions"}],"predecessor-version":[{"id":3399,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3393\/revisions\/3399"}],"wp:attachment":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media?parent=3393"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/categories?post=3393"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/tags?post=3393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}