{"id":3395,"date":"2018-08-10T01:25:54","date_gmt":"2018-08-10T06:25:54","guid":{"rendered":"https:\/\/issels.com\/blog\/?p=3395"},"modified":"2018-08-03T07:19:42","modified_gmt":"2018-08-03T12:19:42","slug":"special-adoptive-t-cell-therapy-reprograms-metabolism-of-cancer-cells-causing-their-death","status":"publish","type":"post","link":"https:\/\/issels.com\/blog\/2018\/08\/10\/special-adoptive-t-cell-therapy-reprograms-metabolism-of-cancer-cells-causing-their-death\/","title":{"rendered":"Special Adoptive T Cell Therapy Reprograms Metabolism of Cancer Cells Causing Their Death"},"content":{"rendered":"
\"New
New Cancer Research is Focused on T Cells<\/figcaption><\/figure>\n

“Everything in moderation” is often cited as the key to balance in life, but scientists are taking a different approach in a new form of cancer treatment<\/a>. According to the results of a recent study, driving up levels of oxidative stress can be fatal to cancer cells<\/a>.<\/p>\n

Reprogramming the Metabolism of Cancer Cells<\/strong><\/p>\n

Reactive oxygen species (ROS) such as peroxide and superoxide are natural byproducts of the metabolism of oxygen, and they play a role in certain cell functions. But while high levels of ROS can kill normal cells and damage DNA, energy-hungry cancer cells consume greater quantities of ROS.<\/p>\n

In a study published in Cell Metabolism<\/em>, a research team at Augusta University examined the effects of adaptive T cell therapy<\/a> on the metabolism of cancer cells. Testing was conducted on mice with large colorectal tumors.<\/p>\n

When Oxidative Stress Becomes Fatal<\/strong><\/p>\n

Adoptive T cell therapy followed treatment with a chemotherapy drug that boosted the activity of the infused T cells. Nearly all the mice experienced complete tumor regression as an apparent result of two factors:<\/p>\n

– Treatment interfered with production of an antioxidant called glutathione, causing ROS levels to rise.<\/p>\n

– T cells increased production of proinflammatory cytokines, chief among them tumor necrosis factor alpha, making cancer cells even more vulnerable to oxidative stress<\/a>.<\/p>\n

Dr. Gang Zhou, author of the study, expressed hope that these findings will help improve immunotherapy treatments by making it easier for T cells to target tumors.<\/p>\n

Personalized Cancer Treatment at Issels\u00ae<\/strong><\/p>\n

Our comprehensive cancer treatment programs<\/a> incorporate therapies that best address a patient’s individual needs. Contact us<\/a> to learn more.<\/p>\n","protected":false},"excerpt":{"rendered":"

“Everything in moderation” is often cited as the key to balance in life, but scientists are taking a different approach in a new form of cancer treatment. According to the results of a recent study, driving up levels of oxidative stress can be fatal to cancer cells. Reprogramming the Metabolism of Cancer Cells Reactive oxygen … Continue reading Special Adoptive T Cell Therapy Reprograms Metabolism of Cancer Cells Causing Their Death<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[205,216,538,1],"tags":[224,509,219,615],"class_list":["post-3395","post","type-post","status-publish","format-standard","hentry","category-immuno-oncology","category-immunotherapy","category-immunotherapy-for-cancer","category-uncategorized","tag-cancer-treatment","tag-immuno-oncology","tag-immunotherapy","tag-immunotherapy-for-cancer-treatment"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3395","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/comments?post=3395"}],"version-history":[{"count":2,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3395\/revisions"}],"predecessor-version":[{"id":3400,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3395\/revisions\/3400"}],"wp:attachment":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media?parent=3395"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/categories?post=3395"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/tags?post=3395"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}