{"id":3419,"date":"2018-08-24T01:50:42","date_gmt":"2018-08-24T06:50:42","guid":{"rendered":"https:\/\/issels.com\/blog\/?p=3419"},"modified":"2018-08-13T18:54:50","modified_gmt":"2018-08-13T23:54:50","slug":"autoimmune-disease-may-hold-a-key-for-more-effective-immunotherapy-treatments","status":"publish","type":"post","link":"https:\/\/issels.com\/blog\/2018\/08\/24\/autoimmune-disease-may-hold-a-key-for-more-effective-immunotherapy-treatments\/","title":{"rendered":"Autoimmune Disease May Hold a Key for More Effective Immunotherapy Treatments"},"content":{"rendered":"
\"Research
Research is Under Way to Cross Out Cancer<\/figcaption><\/figure>\n

Thanks to their ability to avoid detection by the immune system, cancer cells are able to rapidly reproduce and spread. In a major breakthrough, scientists have discovered that a gene associated with hair loss<\/a> could provide valuable clues to improve immunotherapy for cancer<\/a>.<\/p>\n

Autoimmune Disease: The Other Side of the Coin<\/strong><\/p>\n

Ironically, a research team at Columbia University Irving Medical Center (CUIMC) turned to the autoimmune disease alopecia areata as the topic of their recent study, published last June in Cell Systems<\/em>. While cancer is marked by failure of the immune system, alopecia represents the opposite situation, an immune system in overdrive.<\/p>\n

Alopecia results in immune cells attacking and destroying healthy hair cells. During previous research, the CUIMC team isolated a gene called IKZF1 that causes overproduction of T cells in the immune system<\/a>.<\/p>\n

“Flipping the Switch” on the Immune System<\/strong><\/p>\n

In the latest study, the scientists demonstrated that IKZF1 is turned off in many cancer cells<\/a>. The team then set out to test their theory that activating IKZF1 would trigger T cells to begin attacking tumors.<\/p>\n

The study broke down into two parts:<\/p>\n

– When a mouse model of melanoma was engineered to express IKZF1, the corresponding tumors revealed increased levels of immune cells.<\/p>\n

– Analysis of data from a previous study of melanoma patients showed higher recurrence in those with disabled IKZF1.<\/p>\n

Immunotherapy for Cancer: A Personalized Treatment<\/strong><\/p>\n

Immunotherapy for cancer<\/a> programs at Issels\u00ae are focused on boosting your body’s own immune system, so they’re not accompanied by the side effects that frequently accompany conventional treatments such as chemotherapy and radiation.<\/p>\n

Visit our website<\/a> for more information.<\/p>\n","protected":false},"excerpt":{"rendered":"

Thanks to their ability to avoid detection by the immune system, cancer cells are able to rapidly reproduce and spread. In a major breakthrough, scientists have discovered that a gene associated with hair loss could provide valuable clues to improve immunotherapy for cancer. Autoimmune Disease: The Other Side of the Coin Ironically, a research team … Continue reading Autoimmune Disease May Hold a Key for More Effective Immunotherapy Treatments<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[203,205,216,538,1],"tags":[539,509,531],"class_list":["post-3419","post","type-post","status-publish","format-standard","hentry","category-cancer-research","category-immuno-oncology","category-immunotherapy","category-immunotherapy-for-cancer","category-uncategorized","tag-cancer-immunotherapy","tag-immuno-oncology","tag-immunotherapy-for-cancer"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3419","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/comments?post=3419"}],"version-history":[{"count":2,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3419\/revisions"}],"predecessor-version":[{"id":3422,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3419\/revisions\/3422"}],"wp:attachment":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media?parent=3419"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/categories?post=3419"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/tags?post=3419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}