{"id":3523,"date":"2022-12-14T11:15:07","date_gmt":"2022-12-14T16:15:07","guid":{"rendered":"https:\/\/issels.com\/blog\/?p=3523"},"modified":"2022-12-16T09:44:20","modified_gmt":"2022-12-16T14:44:20","slug":"t-cell-senescence-exhaustion-causing-immune-suppression-are-studied-for-potential-therapy","status":"publish","type":"post","link":"https:\/\/issels.com\/blog\/2022\/12\/14\/t-cell-senescence-exhaustion-causing-immune-suppression-are-studied-for-potential-therapy\/","title":{"rendered":"T-cell Senescence & Exhaustion Causing Immune Suppression Are Studied for Potential Therapy"},"content":{"rendered":"

Did you know that cells can become “tired<\/a>?” Researchers explain why new\u00a0discoveries on this topic have implications for improving the effectiveness of cancer immunotherapy<\/a>.<\/p>\n

When T-Cells Lose Their Effectiveness<\/strong><\/p>\n

T-cells, which play a vital role in the immune system’s response to cancer<\/a>, can reach a dysfunctional state known as senescence and exhaustion. Much as in humans, T-cells may get to this point naturally,\u00a0simply as a result of aging. Tumors and tumor microenvironments can also trigger this process.<\/p>\n

Not surprisingly, T-cell exhaustion results in vulnerability to infection, as the immune system loses the strength to fight off foreign\u00a0organisms. Preventive vaccines become less effective, as does the T-cell response to tumor antigens.<\/p>\n

Can T-Cell Exhaustion Be Reversed?<\/strong><\/p>\n

Recent research regarding T-cell exhaustion was reviewed by a team of researchers from Jinan University in Guangzhou, China. Yangqiu\u00a0Li, MD, is lead author of the report, which was published in the Journal of Hematology & Oncology<\/em>.<\/p>\n

The good news, according to Dr. Li’s team, is that scientists have identified candidate biomarkers for T-cell exhaustion, making it easier to conduct targeted research. Eventually, the goal is to discover methods of restoring weakened T-cells to the point where they can again battle tumors with the aid of cancer immunotherapy<\/a>.<\/p>\n

One promising avenue involves the thymus, which is the gland in the lymphatic system that produces T-cells. In studies involving older adult mice, bioengineered\u00a0thymus organoids and combination-cytokine techniques have demonstrated the ability to improve T-cell function.<\/p>\n

State-of-the-Art Cancer Immunotherapy<\/strong><\/p>\n

At Issels\u00ae, our non-toxic, individually tailored immunotherapy programs have helped patients with advanced cancer<\/a> achieve remission, even when other treatments have been unsuccessful. We stay current with research to ensure our protocols incorporate the latest developments.<\/p>\n

Contact us today<\/a> to learn more about “the Issels\u00ae difference.”<\/p>\n","protected":false},"excerpt":{"rendered":"

Did you know that cells can become “tired?” Researchers explain why new\u00a0discoveries on this topic have implications for improving the effectiveness of cancer immunotherapy. When T-Cells Lose Their Effectiveness T-cells, which play a vital role in the immune system’s response to cancer, can reach a dysfunctional state known as senescence and exhaustion. Much as in … Continue reading T-cell Senescence & Exhaustion Causing Immune Suppression Are Studied for Potential Therapy<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":3532,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[580,1],"tags":[229,529,224],"class_list":["post-3523","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer-treatment","category-uncategorized","tag-advanced-cancer-treatment","tag-alternative-cancer-treatments","tag-cancer-treatment"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/comments?post=3523"}],"version-history":[{"count":2,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3523\/revisions"}],"predecessor-version":[{"id":3533,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3523\/revisions\/3533"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media\/3532"}],"wp:attachment":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media?parent=3523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/categories?post=3523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/tags?post=3523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}