{"id":3538,"date":"2022-12-12T15:05:11","date_gmt":"2022-12-12T20:05:11","guid":{"rendered":"https:\/\/issels.com\/blog\/?p=3538"},"modified":"2022-12-12T15:05:11","modified_gmt":"2022-12-12T20:05:11","slug":"how-to-starve-cancer-getting-fuel-from-fat-cells","status":"publish","type":"post","link":"https:\/\/issels.com\/blog\/2022\/12\/12\/how-to-starve-cancer-getting-fuel-from-fat-cells\/","title":{"rendered":"How to Starve Cancer Getting Fuel from Fat Cells"},"content":{"rendered":"

Cancer research is now going beyond the genetic aspect to explore how the disease interacts with the body\u2019s systems. Recent studies of the\u00a0relationship between cancer and fat cells<\/a>\u00a0may have implications concerning\u00a0immunotherapy for cancer<\/a>.<\/p>\n

Feeding the Growth of Cancer Cells<\/strong><\/p>\n

While the precise causes are not yet known, obesity has been identified as a risk factor for\u00a0prostate cancer<\/a>, which is the second leading cause of cancer-related deaths in men. As a result, research into the link between\u00a0cancer and fat cells<\/a>\u00a0has focused on this form of the disease.<\/p>\n

Previous tests involved mice who were fed a high-fat diet. In contrast, researchers at Sanford Prebys Medical Discovery Institute in San Diego conducted a study using mice who lacked a protein called p62, causing them to become obese on a normal diet.<\/p>\n

According to co-author Dr. Jorge Moscat, this control was necessary to get a clear understanding of the communication pathways between cancer and fat cells. The team discovered that p62 suppresses another protein known as mTORC1, which in turn inhibits energy use by fat cells.<\/p>\n

Can Cancer Cells Be \u201cStarved\u201d to Death?<\/strong><\/p>\n

With metabolism halted in fat cells, nutrients are then available to fuel development of tumor cells. Lack of p62 also triggers production of proteins found at high levels in particularly aggressive forms of prostate cancer.<\/p>\n

As explained by Dr. Moscat, these findings can help identify specific substances to be targeted by\u00a0immunotherapy for cancer treatments<\/a>\u00a0with the goal of \u201cstarving\u201d cancer cells.<\/p>\n

State-of-the-Art Immunotherapy for Cancer at Issels\u00ae<\/strong><\/p>\n

Contact Issels\u00ae<\/a>\u00a0for information about our non-toxic, personally developed immunotherapy programs to treat advanced and therapy-resistant cancers.<\/p>\n","protected":false},"excerpt":{"rendered":"

Cancer research is now going beyond the genetic aspect to explore how the disease interacts with the body\u2019s systems. Recent studies of the\u00a0relationship between cancer and fat cells\u00a0may have implications concerning\u00a0immunotherapy for cancer. Feeding the Growth of Cancer Cells While the precise causes are not yet known, obesity has been identified as a risk factor … Continue reading How to Starve Cancer Getting Fuel from Fat Cells<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":3498,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[203,580],"tags":[212,224],"class_list":["post-3538","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer-research","category-cancer-treatment","tag-cancer-research","tag-cancer-treatment"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3538","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/comments?post=3538"}],"version-history":[{"count":1,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3538\/revisions"}],"predecessor-version":[{"id":3539,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/posts\/3538\/revisions\/3539"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media\/3498"}],"wp:attachment":[{"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/media?parent=3538"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/categories?post=3538"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/issels.com\/blog\/wp-json\/wp\/v2\/tags?post=3538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}