Recurring Disseminated Non-Hodgkin’s Lymphoma with Bone Involvement

June 1969
Diagnosis: Lymphoma right neck.

Histology: Undifferentiated malignant lymphoma.

Treatment: Radiation and Chemotherapy.

November 1970
Findings: Disseminated lymphoma, bone marrow contained malignant cells of lymphosarcoma. (Great Ormond Street Hospital for Sick Children, London, England).

No Standard Treatment.

November 1970 to February 1971
Issels Treatment: 12 weeks of in-patient treatment at the Issels hospital and several months of out-patient follow-up treatment.

Discharge exam: Considerable improvement.

November 1971
Recurrence: Bone involvement, infiltration changes in discs, punched out area of destruction in sphenoid, bilateral papilloedema, increased intracraneal pressure, rarefaction of base and vault with separation of sutures, 5 – 10% lymphosarcoma cells in the bone marrow.

November 1971 to January 1972

Issels Treatment: 8 weeks of in-patient treatment at the Issels hospital and several months of out-patient follow-up treatment over the following 2 years.

February 1972
Findings: Considerable improvement, fundal changes back to normal… sutures less wide, sella almost normal.. bone marrow normal. (Great Ormond Street Hospital, London).

November 1977
Findings: Blood Count normal, no indication of further investigation. (Great Ormond Street Hospital, London).

30 years cancer free without any recurrence. D.T. got married, leads a normal life and is fully fit for work.