Issels Integrative Oncology - individualized immunotherapy for over 60 years
September 4, 2014

Ilse Marie Issels, wife of Dr. Joseph IsselsDear Friend,

New technologies are changing how cancer is treated. One of the newest and a truly promising treatment uses nanoparticles to target cancer cells.

From what initial studies show, we might be looking at the future of targeted tumor cell elimination that could one day be combined with immunotherapy, which addresses the underlying tumor microenvironment, further improving chances of stopping the progression of cancer and forcing it into remission.

Best Regards,
Ilse Marie Issels
Ilse Marie Issels
Wife and Collaborator of Dr. Josef Issels, Our Founder



Nanotech Methods May Be the Future of Cancer TreatmentNatural Killer Cells Explained

At Rice University they are blowing up cancer cells with nanoparticle "bombs." Like integrative immunotherapy, the new cancer-fighting technique kills cancer cells without harming surrounding healthy cells. Experimental trials have been so successful in destroying aggressive and resistant cancer cells, particularly in the head and neck areas, that human trials are expected to begin in the near future.

Cancer Bombs

Rice cellular biologist Dmitri Lapolko, who developed the new treatment, calls it quadrapeutics for the four techniques – nanoparticles, laser, drugs and radiation — used in this revolutionary new cancer treatment. Here's how it works (Watch a video.):

1. Colloidal gold nanoparticles filled with a small dose of chemotherapy drugs are injected into the body at the tumor site.

2. The nanoparticles are detonated with a near-infrared laser. The gold magnifies the laser's effect, which allows the use of very small doses of radiation.

3. As the laser hits the nanoparticles, they burst. The energy expansion creates a momentary bubble that blows up and destroys surrounding cancer cells, much like the shock wave from a bomb.

4. Chemotherapy drugs released when the nanoparticles explode deliver a second deadly payload to any remaining cancer cells in the area. With their cell walls already damaged by the nanoparticle explosion, remaining cells are quickly penetrated by the chemo drugs, which are able to directly attack the cytoplasm at the cells’ heart, destroying them.

Cell Therapy

If human trials are successful, Lapolko believes quadrapeutics could be valuable in addressing complex tumors intertwined with critical organs. Increasingly the fight against cancer is being conducted on the cellular battlefield. Visit our website for information about cell therapy in cancer treatments.

Nanotech methods for treatment is a promising way to eliminate cancer tumors. However, as with any tumor-centered method, integrative immunotherapy is still needed to alter the tumor microenvironment and prevent further progression and recurrence of cancer.

We invite you to contact one of our patient care specialists today to chat about how the Issels immunobiologic core treatment program may be the right choice for your health needs. Please call 1-888-447-7357 or visit us online at