Issels Integrative Oncology - individualized immunotherapy for over 60 years
January 29, 2015

Ilse Marie Issels, wife of Dr. Joseph IsselsDear Friend,

Boosting your body's own ability to fight degenerative disease and cancer is one very important element of the success we have had in treating illnesses and a key factor in our unique long term remission results.

As cytokines direct the immune system, they are a substance that plays a very important role in cancer treatment. I think the information you'll read in this issue on will be helpful and interesting.

Best Regards,
Ilse Marie Issels
Ilse Marie Issels
Wife and Collaborator of Dr. Josef Issels, Our Founder



What Exactly Is a Cytokine and How Is It Used in Cancer Treatment?

What is a cytokine and how is it used in cancer treatment?Cytokines are substances secreted by specific cells in your body's immune system. These substances carry the signals that allow cells to communicate with each other. Cytokines may be proteins, peptides or glycoproteins and can interact with your immune system in both positive and negative ways.

What Cytokines Do

Cytokines may act to either enhance or suppress your immune system. Their impact on cell function may be felt locally or at a distance in another part of your body. Despite such functional differences, all cytokines share in the directing of your body's immune response.

It is that ability to impact the functioning of your immune system that makes cytokines such an important factor in cancer treatment. By manipulating cytokines, integrative immunotherapy seeks to modify the dialog between cells. By changing the way cells interact, the goal of integrative immunotherapy is to remove impediments to a healthy immune system and amplify the body's own immune system response to disease.

Using Cytokines in Cancer Treatment

Certain cancer drugs and cancer vaccines have been found to have a noticeable impact on cytokine production. Using vaccines to increase the presence of specific biologic response modifiers such as Interleukin-2 — which the body creates naturally but only in small amounts — floods the body with cancer fighting T-cells and Natural Killer Cells. This sudden influx of immune system-supporting cytokines significantly enhances your immune system's response, giving it extra power to fight off cancer cells.

With over 60 years of clinical experience, Issels Integrative Oncology has been harnessing cancer-fighting benefits in other cytokines such as Interleukin-4, which promotes the generation of dendritic cells, and Interleukin-21, which enhances Natural Killer Cell activity. Visit our website for more information.

We invite you to contact one of our patient care specialists today to chat about how the Issels® Integrative Immunotherapy Program for Cancer may be the right choice for your health needs. We invite you to phone 1-888-447-7357 or visit us online at