Issels Integrative Immuno-Oncology April 27, 2017  

Brain Tumor's Greed for Cholesterol May Create a Treatment Opportunity

Dear Friend,

When it comes to fitness and nutrition, cholesterol has become a bad word. But a team of researchers has discovered that the substance may turn out to be a surprising hero in the fight against cancer.

Brain Cancer Treatment Hits a Dead End

Details of the study, conducted jointly by Ludwig Cancer Research San Diego and Scripps, were published last fall in Cancer Cell. The project involved glioblastoma (GBM), an aggressive and incurable form of brain cancer.

The scientific community had reached an impasse in the treatment of GBM. Although the cancer cells had been extensively studied, targeted therapies based on these analyses proved ineffective and served only to increase the tumor's drug resistance.

Hope Comes from an Unlikely Source

The research team found clues in the way brain cells process cholesterol. The brain actually manufactures its own cholesterol, and when the cells have enough a receptor is activated that starts releasing the excess.

In contrast, GBM cells crave large amounts of cholesterol but do not manufacture it. Their shut-off receptor remains inactive, allowing them to "steal" cholesterol from normal cells and use it to grow.

Researchers implanted GBM tumors from humans into mice and treated them with a drug that triggers the shut-off receptor. As a result, many of the cancer cells were destroyed, causing significant shrinkage in the tumors and extending the lives of the affected mice.

Immunotherapy for Cancer: Treatment for All Forms of Tumors

Our non-toxic, personally developed immunotherapy for cancer programs at Issels® have helped patients with all forms of cancer, from melanoma and lymphoma to breast and lung cancer. Contact us for more information today.

Brain Tumor's Greed for Cholesterol May Create a Treatment Opportunity

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Cancer vaccines train the body’s immune system to target and kill cancer cells, often requiring a boost to the patient’s immune power. A recent study has found a surprising teammate for brain cancer vaccines: the tetanus shot.

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Five Tips to Keeping Healthy After Cancer Treatment

Cancer after care is a vital aspect of ensuring you or a loved one will live a happy, healthy life for years to come. Here are just a few of the best cancer after care tips to help cultivate a long and fulfilling life.

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