Issels Integrative Immuno-Oncology May 17, 2018  

New Advances Improve Treatment for Multiple Myeloma

Dear Friend,

One of the benefits of immunotherapy for cancer is that these treatments often have positive results where others have failed. Results of two recent studies show that immunotherapy has real possibilities for treating multiple myeloma.

What Is Multiple Myeloma?

Multiple myeloma is the second-most diagnosed form of blood cancer, just behind non-Hodgkin's lymphoma. In patients with multiple myeloma, infection-fighting plasma cells grow out of control, causing bone tumors and chronic infections.

Immunotherapy for Cancer: A Promising Treatment for Multiple Myeloma?

In 2017, a research team from Abramson Cancer Center at the University of Pennsylvania conducted two separate studies involving patients with multiple myeloma that had proven resistant to other therapies.

Patients in the first study received a single dose of chemotherapy before being infused with CART-BCMA, a specific form of chimeric antigen receptor (CAR) T-cell therapy developed by Penn researchers in collaboration with Novartis. Results indicated that 64 percent of the group had a positive response.

In the second study, sponsored by GlaxoSmithKline, patients received an experimental monoclonal antibody known as GSK2857916. The drug specifically targets delivery of a chemotherapy drug directly to cancer cells. Overall response rate was 60 percent, with more than half the responding patients experiencing a greater than 90 percent reduction in myeloma protein levels.

Both treatments target BCMA, which is a protein expressed by multiple myeloma cells.

Issels®: The Leader in Immunotherapy for Cancer

Our non-toxic, individually developed immunotherapy programs boost your body's immune system and its natural defense mechanisms. Contact us for more information about our success treating patients with advanced cancer that has resisted other forms of therapy.

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New Advances Improve Treatment for Multiple Myeloma

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Multiple Myeloma Patients React Positively to Car T Cell Treatment

CAR T cells, engineered from a patient's own immune cells, have proved to be a valuable weapon in immunotherapy cancer treatment. Now, recent trials demonstrate that CAR T cells may be effective against advanced multiple myeloma. Unlike more traditional forms of cancer treatment, CAR T cells fall under the umbrella of immunotherapy. A patient's individual immune cells are harvested from their blood, then engineered to target antigens, which are foreign bodies that trigger an immune response.

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Does Treatment Cause Cancer To Spread?

A recent discovery by a team of Israeli scientists has shed new light on the problem. Their study involved mice with multiple myeloma, which is produced in bone marrow and spreads throughout the body. They received treatment with bortezomib, an anti-cancer drug with the brand name of Velcade. The researchers were surprised to find that Velcade caused inflammatory cells in the bone marrow to accelerate the cancer, arming the cells with resistant properties.

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Watch videos of patients who share their own experiences at the Issels clinics with you. Listen to their stories and cancer journeys.

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