Issels Integrative Immuno-Oncology September 13, 2018  

Why Should Immunotherapy Be The Last Resort For Cancer Treatment?

Dear Friend,

While immunotherapy for cancer has provided an exciting new avenue for scientists, there is still much to be learned about which patients will respond, leading to a dilemma for doctors: when all other standard methods have failed, is it ethical to provide cancer patients with new immunotherapy drugs?

If a Little Is Good, Is a Lot Better?

You need to go back only to the 1980s and 1990s for an example of the dangers of treating patients with untested methods. Many doctors began giving women with breast cancer higher-than-usual doses of chemotherapy and radiation based solely on theory, but it turned out that the treatment was worse than the disease.

Immunotherapy drugs that have recently received approval and are restricted to a narrow range of patients have been found to be toxic to the body. Many oncologists won't consider immunotherapy with these drugs as an option outside of their designated uses.

"Desperation Oncology": A Last Chance

Recently, though, oncologists such as Dr. Oliver Sarter of Tulane Medical Center have begun to offer what they refer to as "desperation oncology." The reasoning is that if a cancer patient is terminal and there's even an infinitesimal chance that an immunotherapy drug may help, it's worth the risk.

Not surprisingly, results have been mixed. Drugs had no effect on one patient with bladder cancer who was treated by Dr. Sarter, while another patient with metastatic prostate cancer went into immediate remission upon treatment.

Tailoring Immunotherapy for Cancer to the Patient

We have found that our non-toxic immunotherapy should not be your last chance. At Issels®, we conduct a number of highly specialized tests to ensure that we design a comprehensive course of non-toxic immunotherapy that is appropriate for each patient. Contact us for more information.

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Why Should Immunotherapy Be The Last Resort For Cancer Treatment?

Read more interesting articles on the "Issels Cancer Immunotherapy" news/blog posted every Tuesday and Thursday. Check It Out Now »


New Genetic Tests May Detect Some Asymptomatic Pancreatic Cancers Early

Dr. Aatur D. Singhi and his team at the University of Pittsburgh Medical Center (UPMC) set out to find a way to test pancreatic cysts before surgery, rather than after. The result was PancreaSeq®, a procedure in which fluid is removed from a cyst and tested for 10 different types of tumor genes.

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Tumor Suppressing Protein May Lead To New Pancreatic Cancer Treatments

A research team at the Stanford University School of Medicine tested a variety of p53 mutations on mice that were susceptible to pancreatic cancer. The scientists were surprised to find that one version of the protein kept the mice tumor-free for longer periods of time.

According to Dr. Laura Attardi, senior author of the study, the mutated protein hit a "sweet spot" that allowed embryos to develop without any problems and gave adult mice greater resistance to tumors. The mutation appears to hyperactivate the p53 protein, causing it to affect a number of downstream targets.

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Videos – What Do Patients Say About Their Experience?

Watch videos of patients who share their own experiences at the Issels clinics with you. Listen to their stories and cancer journeys.

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