Some Immunotherapy Drugs May Cause Heart Damage But There Is the Issels Safe Alternative

New Immunotherapy Drugs

New immunotherapy drugs on the market have shown tremendous benefits in battling cancer, but a potentially serious side effect has come to light recently. Some of these drugs, especially when used in combination, may cause heart damage.

Putting the Immune System in Overdrive

In November 2016 the New England Journal of Medicine published a report from a team of experts led by Dr. Javid Moslehi of Vanderbilt University. It involved two melanoma patients who died two weeks after their initial doses of Opdivo and Yervoy, manufactured by pharmaceutical giant Bristol-Myers Squibb.

Opdivo and Yervoy are part of the class of drugs known as checkpoint inhibitors that boost the immune system’s ability to fight cancer cells. In some rare cases, it appears that the immune system also begins attacking the heart and other muscles.

Patient safety records at Bristol-Myers revealed that 18 patients out of 20,594 people receiving one or both drugs had experienced heart inflammation (for a rate of 0.09 percent). The rate increased for patients using both drugs, but it was still less than one percent.

Doctors are Cautious but Optimistic

According to Dr. Jeffrey Sosman of Chicago’s Northwestern University, who treated both patients in the report, overstimulation of the immune system was a known possibility. Many doctors believe drug combos are still the best option for effective treatment, but they are stressing that patients need to be informed of the risk and monitored closely.

IsselsĀ® Has Decades of Experience with Non-Toxic, Safe Immunotherapy for Cancer

Our clinic’s namesake, renowned cancer specialist Dr. Josef Issels, pioneered integrative methods of immunotherapy for cancer dating back to the mid-20th century. Contact us for more information about our safe non-toxic immunotherapy and cancer vaccines.

Brain Tumor’s Greed for Cholesterol May Create a Treatment Opportunity

A Unique Perspective
Fight Brain Cancer With Cholesterol

When it comes to fitness and nutrition, cholesterol has become a bad word. But a team of researchers has discovered that the substance may turn out to be a surprising hero in the fight against cancer.

Brain Cancer Treatment Hits a Dead End

Details of the study, conducted jointly by Ludwig Cancer Research San Diego and Scripps, were published last fall in Cancer Cell. The project involved glioblastoma (GBM), an aggressive and incurable form of brain cancer.

The scientific community had reached an impasse in the treatment of GBM. Although the cancer cells had been extensively studied, targeted therapies based on these analyses proved ineffective and served only to increase the tumor’s drug resistance.

Hope Comes from an Unlikely Source

The research team found clues in the way brain cells process cholesterol. The brain actually manufactures its own cholesterol, and when the cells have enough a receptor is activated that starts releasing the excess.

In contrast, GBM cells crave large amounts of cholesterol but do not manufacture it. Their shut-off receptor remains inactive, allowing them to “steal” cholesterol from normal cells and use it to grow.

Researchers implanted GBM tumors from humans into mice and treated them with a drug that triggers the shut-off receptor. As a result, many of the cancer cells were destroyed, causing significant shrinkage in the tumors and extending the lives of the affected mice.

Immunotherapy for Cancer: Treatment for All Forms of Tumors

Our non-toxic, personally developed immunotherapy for cancer programs at IsselsĀ® have helped patients with all forms of cancer, from melanoma and lymphoma to breast and lung cancer. Contact us for more information.