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Cancer Research, Immunotherapy

Immune Cells May Hold Key to Brain Cancer Treatment

Immune Cells
Immune Cells

The immune system is your body’s natural protective force. When cancer cells develop or when foreign substances invade your body, your immune system goes on the attack, sending specialized cells to target these “foreign” invaders.

Highly specialized immune system cells called microglia protect the brain. While examining brain cancer tumors in diseased mice, Canadian researchers found deactivated microglia. When these cells were reactivated, the mice lived two to three times longer than untreated mice with the same type of brain tumor.

A joint effort by research teams at the University of Calgary Hotchkiss Brain Institute and Southern Alberta Cancer Research Institute, the discovery may eventually lead to new immunotherapy treatments for brain cancer, although researchers say additional research is needed before clinical trials can be contemplated. The Canadian study focused on glioblastoma tumors, the deadliest form of brain cancer. Fifteen months is the median survival rate for glioblastoma patients. Even with currently available treatments, fewer than one in 20 pass the five-year survival mark.

In Medical News Today (MNT), study author V. Wee Yong, who holds a Canada Research Chair in Neuroimmunology, explained that inactivated microglia are a normal result of the battle between immune cells and cancer cells. Over time, aggressive tumor cells can overwhelm the brain’s immune system, deactivating its defender cells. Reactivating these cells can “tip the battle in favor of the brain to suppress the tumor,” Yong said.

The Canadians used a highly caustic drug to restore function to the brain’s immune cells. Issels cancer treatments strengthen and enhance immune system function using non-toxic integrated immunotherapy to avoid the destructive side effects of harsh drugs.

Alternative Cancer Treatment, Cancer Research

How Do T-Cells Help Fight Cancer?

T Cells
T Cells

Cancer cells appear to a well-functioning immune system as “foreign” cells. When cancer cells develop the immune system swings into action, using a dual action force to knock them out just as it does with foreign invaders. First your immune system launches innate responders like Natural Killer Cells to seek out and attack these cells (see our previous post). Your body’s first line of defense against cancer cells, viruses, bacteria and other harmful substances, Natural Killer Cells are the equivalent of the immune system’s Seal Team 6.

Adaptive responders like T-cells provide the immune system’s second wave of defense. Like an army’s occupying force, T-cells support Natural Killer Cells and other immune system “specialists” to provide your body with continuous, long-term protection.

Like Natural Killer Cells, T-Cells are a type of lymphocyte that originates in the bone marrow. T-cells eventually migrate to the thymus from which they get the “T” in their name. A specialized organ of the immune system, the thymus straddles the trachea and is located in the lower neck below the thyroid gland. In the thymus, T-cells undergo their final stage of maturation and receive their marching orders.

There are several different types of T-cells, each tasked with playing a specific role in helping with the recognition, attack and destruction of cancer cells and harmful invaders.

Issels Autologous Vaccine stimulates the formation and activation of T-cells. When used in conjunction with Issels integrative immunotherapy, autologous vaccines can strengthen and enhance your body’s immune system response to cancer cells. Visit our website to find out more.

Cancer Research, Immunotherapy

How Do Natural Killer Cells Fight Cancer?

Fighting Cancer Naturally
Fighting Cancer Naturally

Natural Killer Cells, or NK Cells, could be considered the body’s elite fighting force. These cellular warriors form the body’s first line of defense when it is invaded by viruses or other harmful agents and when it detects aberrant cells such as cancer cells that appear as “foreign”.

Living up to their name, Natural Killer Cells attack and kill tumor cells and virus-bearing cells by bombing them with protein granules. That these attacks take place at the microscopic level makes them no less devastating. Bombarded by a fuselage of protein “bombs,” tumor cells disintegrate and die in a process known as apoptosis, or programmed cell death.

The body’s immune system is divided into two divisions:

• Innate responders, such as Natural Killer Cells, form the front lines of your immune system’s defensive force, providing immediate defense when cancer cells develop.

• Adaptive responders, which include T-cells (more about them next time), are your immune system’s occupying force, providing long-lasting protection and immunity from future attacks.

Natural Killer Cells evolve from lymphoid stem cells which originate in your bone marrow, as do all immune system cells. Lymphoid stem cells produce the lymphocytes that identify foreign invading organisms and “foreign” appearing cancer cells, so they can be targeted by the immune system. Administration of Issels Autologous Lymphocyte cancer vaccine may be included in individualized integrated immunotherapy programs to enhance immune system response and promote the activation of NK Cells.

Natural Killer Cells have been shown to eliminate solid tumors and metastatic cells circulating in the blood stream. A 2009 analysis of 129 cancer patients who underwent Issels Out-Patient Cancer Treatment at our Santa Barbara, California medical center showed an average 48% increase in absolute NK Cell levels after three weeks.

Alternative Cancer Treatment, Cancer Research

Using Thermal Therapy to Fight Cancer

Alternative Cancer Therapy
Alternative Cancer Therapy

Fever is one of the natural defensive weapons your body uses to fight infection. When bacteria, viruses, toxins or other foreign invaders cause infection, your body turns up the heat. Under the guidance of knowledgeable and experienced physicians, this powerful immune system response can be used to help fight cancer via a therapy known as Hyperthermia.

Also called Thermal Therapy or Fever Therapy, Hyperthermia is the deliberate heating of the whole body or affected parts of the body for therapeutic purposes. For many patients at Issels Alternative Cancer Treatment Centers, thermal therapy has proven to be a valuable and effective component of integrative cancer treatment.

Fever Therapy has a long history of medical use dating back centuries but fell out of favor with the traditional medical community with the rise of the pharmaceutical industry and development of fever-reducing drugs such as aspirin and acetaminophen. More recently, practitioners of western medicine have begun to realize that the body knows best.

As Discovery Fit & Health explains, “It used to be standard medical practice to knock that fever out as quickly as possible. Not so anymore. The value of fever is recognized.”

Hyperthermia is now being used to treat cancer at several university hospital centers in the U.S. and Europe; however, our founder, Dr. Josef Issels, recognized the value of invoking this powerful immune response in the treatment of cancer in the early 1950s. Trained in Dr. Issels’ effective techniques, Issels’ cancer treatment teams have extensive experience administering hyperthermia in the treatment of cancer. Visit our website to find out more about thermal therapy and our non-toxic integrated immunotherapy approach to cancer treatment.

Alternative Cancer Treatment, Cancer Survivors

Amish Girl Who Fled U.S. to Avoid Chemo Is Cancer-Free After Alternative Therapy

Childhood Cancer
Childhood Cancer

That 11-year-old Sarah Hershberger is cancer-free after undergoing alternative cancer treatments is wonderful news. That Sarah and her family had to flee the country to obtain the treatment that has made her healthy and are being treated like fugitives by their own country is considered by many Americans to be a travesty of justice and a breach of personal liberty.

If Sarah were an adult, her desire to stop the chemotherapy that was making her horribly ill and pursue non-toxic alternative cancer therapies would be respected and considered her decision to make. However, because Sarah was 10 years old when she was diagnosed with leukemia, those decisions were made by her parents.

Perhaps unwilling to look beyond the limited cancer treatment options offered by traditional medicine, the hospital administering the chemotherapy sued to force Sarah to continue treatments they believed would save her life. Unwilling to subject their daughter to more unbearable pain and suffering, Sarah’s parents left the comfort and support of their family and Ohio Amish community and fled the country with their daughter to obtain the alternative treatments they were convinced would make her well. Shortly after the family went into hiding the court appointed the hospital’s attorney, who is also a nurse, Sarah’s legal guardian with the power to direct her cancer treatments. Sarah’s parents have appealed the ruling and remain in hiding, although they have reportedly returned to the U.S.

Despite the hospital’s warnings, Sarah’s grandfather reports that Sarah is doing well and the “treatments are working.” He recently told the Associated Press that “blood and imaging tests” show that Sarah is now cancer-free.

Cancer Research, Immunotherapy

New Research Finds Tantalizing Similarities between Aging and Cancer Cells

Similarities to Aging and Cancer Cells
Similarities to Aging and Cancer Cells

That cancer risk dramatically increases with age is a known fact. But why that is so has puzzled scientists. The general assumption has been that living longer simply increases our exposure to cancer-causing agents. However, a new study recently published in the journal Nature Cell Biology indicates that the very process of aging may play a major role in the connection between increased cancer risk and aging.

In studying the aging process of connective tissue cells, called fibroblasts, a team of Scottish researchers discovered aging cells exhibit many of the same DNA changes that occur in cancer cells. As explained on arstechnica.com, as we age our cells go through a process called senescence which causes changes to the epigenome. The epigenome consists of the proteins and biochemical compounds that attach to and can alter our DNA. While not actually part of our DNA, epigenetic alterations can be passed from cell to cell during cell division.

When aging cells enter senescence, changes in the epigenome direct cells to stop dividing; however, as cells age they begin to lose control over their epigenome, leaving it more vulnerable to modification. Scottish researchers discovered that the epigenetic modifications that occur during senescence are remarkably similar to the epigenetic changes observed in cancer cells. Scientists hope the revelation will take them a step closer to solving the puzzle of how cancer cells are able to continue multiplying and ignore genetic imperatives to stop dividing.

Like the tumor microenvironment targeted by Issels integrative immunotherapy, the epigenome may turn out to play a surprising role in cancer treatment.