Tag Archives: New Cancer Treatment

“Superblood” Engineered to Carry Cancer Fighting Proteins

"Superblood" Engineered to Carry Cancer Fighting Proteins
“Superblood” Engineered to Carry Cancer Fighting Proteins

Super powers are usually the stuff of comic books and movies, but a biotech startup may be turning fiction into reality with the development of “superblood” as a revolutionary new cancer treatment.

“Supercharging” Red Blood Cells

Rubius Therapeutics is working on a program called Red-Cell Therapeutics (RCT), which involves red blood cells that are genetically engineered to fight cancer. Once introduced into a patient’s system, these proteins can replace missing enzymes and help the immune system attack and destroy cancer cells.

RCT has two major advantages that make it a promising breakthrough in cancer treatment:

– The nuclei have been removed from these cells so they can’t be recognized by the immune system, leaving them free from interference so they can do their job.

– Red blood cells travel throughout the entire body, so RCT is able to easily reach any affected organs or tissues.

Thanks to these two features, RCT has the potential to treat patients without the need for an individually developed solution.

What’s Next?

Initially, Rubius Therapeutics generated $120 million from investors. The company recently raised an additional $100 million for a total of nearly a quarter of a billion dollars in less than one year. According to Rubius president Torben Straight Nissen, this funding will help accelerate RCT development for quicker delivery to the end users.

Issels®: The Leader in Immunotherapy Cancer Treatments

Much like RCT, cancer treatment at Issels® is designed to boost the immune system’s ability to attack and kill cancer cells. Contact us to learn more about cancer vaccines and other programs we have used to help patients achieve long-term remission.

Immunotherapy is Changing Cancer Treatment Again in Exciting New Ways

Immunotherapy is Changing Cancer Treatment Again in Exciting New Ways
Immunotherapy is Changing Cancer Treatment Again in Exciting New Ways

If you think you’ve been hearing the term “immunotherapy” a lot lately, it’s not your imagination. Scientists consider this growing form of cancer treatment to be a game-changer on a par with the polio vaccine and organ transplants.

Researchers Commit to Immunotherapy

The University of Pittsburgh Medical Center, one of the top-rated health enterprises in the U.S., recently demonstrated their major commitment to immunotherapy research. Earlier this year, they announced plans for a $200 million Immune and Transplant Therapy facility to open in 2020.

UPMC’s newest center will focus on researching treatments to disrupt cancer growth as well as reduce the need for immune-suppressing drugs with transplant patients. Dr. Robert Ferris, director of UPMC’s Hillman Cancer Center, referred to the facility as “swinging for the fences.”

How Immunotherapy Works

Immunotherapy cancer treatments fall into one of two categories:

Checkpoint modulator drugs trigger the body’s own immune cells to attack and destroy cancer cells.

– Cell therapies, such as the recently approved CAR-T therapy, involve harvesting a patient’s T-cells and programming them to fight cancer cells, at which point they are reinfused back into the patient’s system.

Dr. Sandip Patel of the University of California San Diego called immunotherapy a “paradigm shift” in cancer treatment. According to Patel, when immunotherapy is effective, it can lead to a patient’s cancer going into remission for years.

Issels®: A Pioneer in Immunotherapy Cancer Treatments

Our founder, Dr. Josef M. Issels, predicted the rise of immunotherapy more than 20 years ago. Visit our website to learn more about Issels® and our innovative approach to non-toxic, individually created cancer treatment programs.

New Blood Test Created by Johns Hopkins to Screen for Eight Cancers

New Blood Test Created by Johns Hopkins to Screen for  Eight Cancers
New Blood Test Created by Johns Hopkins to Screen for Eight Cancers

Early detection often makes the difference in successful cancer treatment. Thanks to a newly developed blood test, doctors will soon be able to screen for eight of the more common types of cancer.

Focusing on Early Stage Cancer Detection

CancerSEEK was developed by a team of scientists at Johns Hopkins Kimmel Cancer Center. It screens for cancers of the ovaries, liver, stomach, pancreas, colorectum, lung and breast. Collectively, these types are responsible for more than 60 percent of cancer deaths in the United States.

Based on the idea that circulating tumor DNA mutations can be specific cancer markers, the researchers set out to study several hundred genes and 40 protein markers. They finally ended up with segments of 16 genes and eight proteins, with the small mutation panel minimizing the possibility of false-positive results.

According to Nickolas Papadopoulos, senior author of the study, the team was inspired by the concept of using combinations of drugs for cancer treatment. When the test was administered to 1,005 patients with non-metastatic cancer, its median overall sensitivity to cancer was 70 percent with only seven false-positives.

The Future of CancerSEEK

Researchers are proceeding to larger studies of CancerSEEK. They project that once the test is approved for use the cost will be less than $500, and primary care providers will be able to administer the test with other routine blood work.

Cancer Treatment for Therapy-Resistant Tumors

Our non-toxic immunotherapy programs have been successful with advanced cases of all types of cancer, including breast, lung and colorectal. Contact us to learn more about state-of-the-art cancer treatments at Issels®.

Hard to Fight Pancreatic Cancer Responds to Immunotherapy

New Cancer Treatment For Pancreatic Cancer
Pancreatic Cancer Treatment News: Chemotherapy Plus Immunotherapy

Pancreatic cancer is one of the more difficult forms to diagnose, resulting in a low survival rate. A recent study found that immunotherapy for cancer holds great promise for more effective treatment.

Current treatments for pancreatic cancer

Surgery is the best option for pancreatic cancer. Unfortunately, the tumors are often discovered too late for surgery to be feasible. Doctors are left to use chemotherapy and other methods to control the cancer.

Medical breakthrough with immunotherapy

Researchers at University of Rochester Medical Center in New York set out to find a treatment that could make pancreatic cancer more receptive to surgery. The test involved use of PF-0416309, an immunotherapy drug that targets immune cells in pancreatic tumors.

Subjects included 47 patients whose pancreatic cancer had begun to spread. Eight received chemotherapy alone, while the others received a combination of chemotherapy and the immunotherapy drug.

Most of those who received the combination experienced a halt in the tumor’s growth, which was double the rate projected by the research team. Some saw their tumors shrink, while in one patient the cancer disappeared.

What’s next?

Side effects forced three patients to drop out, but otherwise no one had side effects more serious than those with chemotherapy alone. The researchers now plan to extend the scope of the test with phase 2 trials.

Issels® is the leader in immunotherapy for cancer

For years, our Issels® center has been ahead of the curve on immunotherapy for cancer. Our treatment programs are created individually,

based on each patient’s specific needs. Visit our website to learn more about cancer vaccines and other non-toxic immunotherapy treatments.

Watchful Waiting – A New Treatment for Some Breast Cancer Patients

New Treatment for Breast Cancer
New Treatment for Breast Cancer

Despite significant improvements in cancer treatment, such as the development of immuno-oncology, patients often have a knee-jerk reaction to a cancer diagnosis. This may be particularly true for women, who are mindfully watching the efforts to increase public awareness of breast cancer. They may feel that there are mixed messages in the news in regards to the appropriate treatment for their breast cancer.

Some women, along with their physicians, have begun taking a path that may seem counterintuitive. They are choosing to defer traditional treatments, such as chemotherapy and lumpectomy, in favor of a course often referred to as “watchful waiting.”

What is watchful waiting?

Desiree Basila, a 60 year-old woman diagnosed with DCIS or stage 0 breast cancer, participated in a clinical trial that exemplifies watchful waiting. She began taking tamoxifen, a drug that blocks estrogen, which can often cause tumors to grow. In addition, she visited her doctor twice a year for checkups that alternated between mammograms and MRIs.

The reasons behind watchful waiting

  • Studies show that women with DCIS have a mortality rate of three percent regardless of their form of treatment, which corresponds to the average for the general population.
  • Each case of breast cancer is unique based on a woman’s biological profile, meaning treatment should be determined on an individual basis rather than using a cookie-cutter approach.
  • Mastectomy, radiation and other aggressive treatments sometimes cause seriously harmful side effects that may have been avoided with a more moderate approach.

Assessment of a patient’s individual lifestyle, genetic profile and personal needs has always been a part of our immuno-oncology protocols at Issels®. Visit our website to learn more about our innovative and non-toxic cancer treatment programs.

Designer Cancer Therapies using Your Body to Fight Cancer

Alternative Lung Cancer Treatment
Fighting Cancer With Your Body

Dealing with the challenges of stage four cancer treatment can feel overwhelming and isolating, but there is good news. Doctors, scientists and researchers are working hard to make advances in cancer prevention and treatment and their efforts are paying off. The latest breakthrough involves creating a personalized vaccine that is designed to target each patient’s cancer.


Research shows that one of the best ways to fight cancer is to harness the power of the body’s own immune system. A personalized vaccine does this by telling your immune system to target a tumor. The result is a more focused treatment that isn’t as hard on the rest of your body as radiation or chemotherapy.

No Two Cancers are Alike

Every cancer patient experiences tumors behave differently. That is why a one-size-fits-all approach to stage four cancer treatment simply won’t be as effective as a more concentrated and personalized effort. Immunotherapy actually identifies the genes that are causing mutations and creates a vaccine that will specifically target those cells. This minimizes side effects and produces better results.

Developing Vaccines

A this stage in the process, scientists are still collecting data and trying to streamline all the various components involved in creating a vaccine. It takes time for them to produce a personalized vaccine. Cutting down on turnaround time could significantly increase the number of patients who are able to benefit from this specialized type of therapy.

Immunotherapy and personalized vaccines are just two components of an individualized treatment plan. At Issels®, we have many years of experience in preparing and administering personalized vaccines and also incorporate new methods as they are available. We take a comprehensive individualized approach to treatment because we know that cancer is a very complex systemic disease and every patient is different. Contact us today to find out more.