Could This Bacterial Molecule Stimulate the Immune System to Fight Cancer?

Get The Treatment You Need with Us!
Get The Treatment You Need with Us!

There’s a popular saying that goes, “Everything old is new again.” This may also hold true with immunotherapy for cancer, as researchers explore the possibility of enlisting your body’s ancient defenses against bacterial threats to fight tumors.

Going Back to the Future

A team at Fred Hutchinson Cancer Research Center in Seattle recently conducted a trial of an experimental drug on 15 patients with advanced sarcoma. The drug, known as G100, was based on a molecule called lipopolysaccharide that is carried within certain bacteria.

Lipopolysaccharide is unique to these organisms, so its presence has historically triggered a prompt and powerful inflammatory response. According to scientists, the pathway to this response dates back so far in the evolutionary cycle that it’s nearly identical in all animals.

Over a period of two to three months, participants received an injection of G100 directly into the tumor, along with a course of focused radiation. The injected tumors stopped growing, shrank or even disappeared in 14 of the 15 patients, while tumor growth throughout the body stopped in six of them.

Boosting the Body’s Immune System

Researchers are theorizing that the drug makes the tumor “hot” in terms of activating an immune response aimed specifically at the cancer cells. The next step involves combining G100 injections with an as-yet-undecided immunotherapy agent to see if the treatment can boost the cancer-fighting immune response throughout the body.

Using State-of-the-Art Methods to Fight Cancer

At Issels®, we stay up-to-date on all the latest advancements in immunotherapy for cancer. Contact us to learn more about our non-toxic, integrative treatment programs that are specifically designed for your individual needs.

Tumor Treating Fields (TTF) Emerge as a New Cancer Treatment

New Advances Are Being Made in Cancer Treatment
New Advances Are Being Made in Cancer Treatment Using TTFields

Brain cancer is one of the more difficult forms to treat, with the last advancement dating back more than 10 years. Today scientists are excited about the potential of tumor-treating fields (TTFields) as a means of “shocking” cancer cells.

Putting a “Charge” into Cancer

TTFields were first approved as a cancer treatment by the US Food and Drug Administration in 2011. The method of sending mild electrical fields through the scalp was originally used to treat glioblastoma, the most aggressive form of brain cancer that carries a two-year survival rate of approximately 30 percent.

NovoCure’s device, Optune, is a patient-controlled system that uses adhesive patches to deliver low-electric fields with a frequency of 200 kHz. The fields pulse through the skin, where they are thought to block the division of cancer cells.

TTFields in Action

There have been several subsequent trials of Optune that have generated positive results, but the most recent trial has been described as “landmark.” Neurologist Roger Stupp of Northwestern University led a group of researchers in a five-year study of patients newly diagnosed with glioblastoma.

Out of 695 participants, one-third were treated with oral chemotherapy alone while the other two-thirds had the oral treatment coupled with the Optune device. The two-, three-, four- and five-year survival rates were all significantly higher for the group that received the combination treatment.

Issels®: The Leader in State-of-the-Art Cancer Treatment

We’ve seen a significant number of patients achieve long-term remission after receiving our integrative immunotherapy programs. Contact us today to learn how Issels® has been ahead of the industry in the use of individually-developed immunotherapy protocols for cancer treatment.

The Cost of Some New Cancer Drugs Spiral Out of Reach for Some Patients

The Cost of Some Medications Is Rising
The Cost of Some Medications Is Rising

The last few years have brought exciting advances in immunotherapy for cancer, but innovation has come at a price … literally. Skyrocketing costs for cancer drugs are making them inaccessible for many who would benefit the most.

Cancer Drugs: The Price of Success

During the 10-year period between 2005 and 2015, Big Pharma’s pipeline of cancer drugs increased by 63 percent, with several reaching the market. As a result, the global market is projected to grow from $16.9 billion in 2015 to an astounding $75.8 billion in 2022.

But while competition generally serves to drive prices down, that’s not happening with the new cancer drugs. Factors such as market exclusivity, insurance plan structures and lack of head-to-head comparison studies combine to keep prices high.

One example is checkpoint inhibitors, which release the systemic “brakes” preventing the immune system from recognizing and attacking cancer cells. Bristol, Merck, Roche and Pfizer all have checkpoint inhibitors on the market, but each has an annual price tag approaching $150,000.

What’s the Answer?

Experts see no evidence that pharmaceutical companies, driven by the current free rein on pricing, are exploring more cost-effective solutions. President Donald Trump and lawmakers from both parties are prioritizing a search for methods to restrain spiraling cancer drug costs, ranging from more price negotiation to faster approval.

Issels® Leads the Field in Immunotherapy for Cancer

While the medical community and lawmakers grapple with the finances of immunotherapy for cancer, we have been successfully treating patients with individually developed non-toxic protocols for years. Contact us today to learn more about cancer vaccines, NK cells and other immunotherapy programs at Issels®.

Could Where You Live in Your Time Zone Affect Your Cancer Risk?

Does Your Time Zone Impact Cancer?
Tired When You Get Up? Could Your Time Zone Impact Cancer?

While the hour may be the same throughout a time zone, the degrees of sunlight and darkness are not. A recent study suggests that this quirk of nature may be linked to an increased cancer risk.

When Day Becomes Night

A research team at the National Cancer Institute was inspired by previous research showing slightly higher cancer risk among people who work the night shift. This finding was attributed to circadian disruption, which is a change in the body’s biological clock.

Shift workers experience extreme circadian disruption owing to almost complete reversal of day and night. The NCI researchers set out to see if the increased risk of cancer applied to minor disruptions in the body’s natural rhythms, referred to as social jet lag.

The most common example of social jet lag is rising at different times on work days and weekends, but the phenomenon also occurs with people living on either end of a time zone, where light and dark come at different times.

Effects of Social Jet Lag on Cancer Risk

After reviewing data from 4 million white adults who had been diagnosed with cancer, the NCI team found each five degrees of longitude toward the west resulted in an increased risk of three percent for men and four percent for women. Greater risk was also found specifically for breast cancer, prostate cancer and uterine cancer.

Issels®: Leading the Way in Immunotherapy for Cancer

Our Issels® clinic has been in the forefront of state-of-the-art immunotherapy for cancer treatments. Contact us to learn more about our personally tailored integrative programs.

In the News: Low Dose Aspirin Reduces Cancer Death Risk

Low Dose Aspirin Therapy
Low Dose Aspirin Therapy May Reduce Cancer Death Risk

Could aspirin become a powerful weapon in immunotherapy for cancer? Researchers have found evidence that a daily regimen of low-dose aspirin may lower the mortality rate of cancer patients.

An Aspirin a Day

Aspirin is an anti-inflammatory drug that has been used as a pain reliever since the days of ancient Egyptians. In early April, attendees at the American Association for Cancer Research meeting in Washington, D.C. learned why aspirin also holds promise for treating cancer patients.

Yin Cao, an instructor at Massachusetts General Hospital and Harvard Medical School, reviewed data from long-term health studies involving both men and women. While the overall risk of death was lower for individuals who took a daily dose of aspirin, Cao found that the risk of dying from cancer was 7 percent lower in women and 15 percent lower in men.

The connection was most dramatic with colorectal cancer, as women had a 31 percent lower risk and men’s risk was 30 percent lower. Significant reductions were also found among women with breast cancer and men with prostate or lung cancer.

Is Aspirin Treatment for Everyone?

Despite the encouraging results, Cao offered a note of caution for anyone considering this course of medication. Aspirin increases risk of ulcers and gastrointestinal bleeding, so Cao emphasized the importance of consulting with your doctor before undertaking a daily program.

Issels®: Fighting Cancer and Its Causes

Our immunotherapy for cancer treatment programs go beyond eliminating tumors to helping your immune system regain its natural defense mechanisms. Contact us to learn more about cancer vaccines and our other personally tailored integrative programs.

Transformative Impact of Immunotherapy Tops Cancer News

Diverse Hands Holding The Word Cancer
Immunotherapy brings breakthroughs to cancer treatment.

For decades, cancer has been the main focus of innumerable medical researchers. During 2016, immunotherapy for cancer was designated the top advance in the field for the second consecutive year.

The Rapid Rise of Immunotherapy Treatment

The announcement was made in Clinical Cancer Advances 2017, the 12th annual report from the American Society of Clinical Oncology (ASCO). Dr. Daniel F. Hayes, president of ASCO, presented the report to Congress during a recent meeting to request continued funding for cancer research.

According to Dr. Hayes, immunotherapy was a “promising theoretical treatment” less than 10 years ago. In a relatively short span of time, it has become a “standard of care” that has positively affected thousands of patients.

“Immunotherapy 2.0”

Just how much progress has been made in immunotherapy for cancer? Since 2011, a total of 15 immune-targeted therapies have been approved. That success combined with continued improvements in identifying candidates and overcoming resistance mechanisms, led ASCO to dub it “Immunotherapy 2.0.”

Dr. Hayes also stressed the importance of federal funding in maintaining the momentum in cancer research. One prominent development that has made a significant impact is the Cancer Moonshot program. Former Vice President Joe Biden took up the cause after his son Beau’s death from brain cancer.

Issels®: Ahead of the Curve

While the rest of the medical community is embracing the value of immunotherapy for cancer, we have been in the forefront of successfully treating patients by boosting their own immune systems. Visit our website to learn more about cancer vaccines, NK cells and our other non-toxic, individually tailored programs.

 

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