Tag Archives: Cancer Cell Growth

Is Cancer Inevitable?

Future Cancer Prevention Techniques
Future Cancer Prevention Techniques

That cancer risk increases with age is a statistical truth. But does this mean that cancer is inevitable, as George Johnson recently suggested in the New York Times? In an article that has generated a fair amount of debate, the author of The Cancer Chronicles implies that cancer might be a necessary part of a larger plan.

“The rhetoric about the war on cancer implies that with enough money and determination, science might reduce cancer mortality as dramatically as it has with other leading killers – one more notch in medicine’s belt. But what, then, would we die from?”

Like many others, Johnson seems to believe that the simple act of living longer gives cancer cells more time to develop. The very nature of cell replication opens the door to cancer in what Johnson calls “the result of a basic evolutionary compromise.”

“As the body lives and grows, its cells are constantly dividing, copying their DNA. … They in turn pass it to their own progeny: copies of copies of copies. Along the way, errors inevitably occur.”

When the body fails to repair these genetic “glitches,” cancer cells can develop. “As people age their cells amass more potentially cancerous mutations,” Johnson says. “Given a long enough life, cancer will eventually kill you.”

Johnson does recognize that progress against cancer is being made. “New immune system therapies that bolster the body’s own defenses have shown … promise,” he notes, also mentioning the potential of targeted genetic therapy and nano robots to advance the cancer fight to the next level. But at the end, even if we can extend our lives into a second century, Johnson believes, “waiting at the end will be cancer.”

Next time: A different view: Hope IS warranted

WHO Predicts Worldwide Cancer Increase

Cancer Research
Cancer Research

Researchers are making progress in combating cancer, particularly in the United States and other industrialized nations where medical treatment is readily available. But in the rest of the world, cancer is on the rise, according to a new report by the World Health Organization (WHO). As developing countries adopt modern lifestyles, cancer rates are increasing. According to WHO, cancer cases worldwide could surpass 19 million by 2025.

Between 2008 and 2012, cancer diagnoses worldwide grew from 12.7 million to more than 14 million and deaths from cancer rose from 7.6 to 8.2 million. By the end of the next decade, WHO expects the number of people diagnosed with cancer to begin approaching the 20 million mark, which would be a significant jump over the current worldwide cancer growth rate.

As developing countries become more industrialized, smoking, obesity and longer life spans are contributing to an increased risk of cancer, according to a BBC News health report. Lung cancer, primarily from cigarette smoking, poses the greatest risk, accounting for 13% of total cancer cases, or about 1.8 million diagnoses, worldwide. WHO also cited a significant rise in the global number of breast cancer cases; noting that breast cancer has become the most common cancer among women in 140 countries.

“Breast cancer is also a leading cause of cancer death in the less developed countries of the world. This is partly because a shift in lifestyles is causing an increase in incidence and partly because clinical advances to combat the disease are not reaching women living in these regions,” Dr. David Forman of WHO’s International Agency for Research told BBC News.

New Research Finds Tantalizing Similarities between Aging and Cancer Cells

Similarities to Aging and Cancer Cells
Similarities to Aging and Cancer Cells

That cancer risk dramatically increases with age is a known fact. But why that is so has puzzled scientists. The general assumption has been that living longer simply increases our exposure to cancer-causing agents. However, a new study recently published in the journal Nature Cell Biology indicates that the very process of aging may play a major role in the connection between increased cancer risk and aging.

In studying the aging process of connective tissue cells, called fibroblasts, a team of Scottish researchers discovered aging cells exhibit many of the same DNA changes that occur in cancer cells. As explained on arstechnica.com, as we age our cells go through a process called senescence which causes changes to the epigenome. The epigenome consists of the proteins and biochemical compounds that attach to and can alter our DNA. While not actually part of our DNA, epigenetic alterations can be passed from cell to cell during cell division.

When aging cells enter senescence, changes in the epigenome direct cells to stop dividing; however, as cells age they begin to lose control over their epigenome, leaving it more vulnerable to modification. Scottish researchers discovered that the epigenetic modifications that occur during senescence are remarkably similar to the epigenetic changes observed in cancer cells. Scientists hope the revelation will take them a step closer to solving the puzzle of how cancer cells are able to continue multiplying and ignore genetic imperatives to stop dividing.

Like the tumor microenvironment targeted by Issels integrative immunotherapy, the epigenome may turn out to play a surprising role in cancer treatment.

Tea or Coffee: Which Is Better at Preventing Cancer?

Coffee's Ability to Help Cope With Cancer
Coffee’s Ability to Help Cope With Cancer

Coffee or tea? Whichever side of the beverage debate you stand on, you’ll be pleased to know that both popular beverages offer health benefits that may help prevent certain types of cancer. If you are already fighting cancer, substances in coffee and tea may boost your immune system and improve mind-body function, enhancing your ability to cope with the stress of having cancer.

Here’s a rundown on the latest findings (some findings are preliminary or based on small samplings, but all offer provocative avenues for further research):

Coffee. If you’re one of those people who can’t get their motor revving in the morning without a jolt of java, you’ll be happy to know that your morning cup of coffee comes with quite a few unsuspected benefits. If coffee gives you heartburn, try a darker roast. A substance in dark roast coffees inhibits the production of stomach acid. Just remember; as in all things, moderation is the key. The benefits listed are based on consumption of 2 to 4 cups of coffee per day.

  • Skin cancer. Just one cup of coffee a day may lower melanoma risk by 11%. Coffee may also aid cell repair and help the body absorb harmful ultraviolet rays, decreasing skin cancer risk.
  • Endometrial cancer. Coffee decreases the body’s levels of estrogen and insulin which may help lower endometrial cancer risk.
  • Mind-body benefits. Women benefit from coffee drinking more than men. Drinking 3 cups of coffee a day can lower women’s risk of depression by 15%. Drink a fourth cup of coffee and depression risk drops by 20%. Coffee also helps women cope with stress.

Next time: Tea benefits

 

Young Adults Have Higher Risk of Oral Cancer

Fight Oral Cancer
Fight Oral Cancer

Once considered an old man’s disease, oral cancer is making a comeback; only this time it’s targeting young adults. Oral cancer is now the sixth most common cancer among young adults in their 20s and 30s. More than 40,000 Americans are diagnosed with oral cancer every year, according to the Oral Cancer Foundation. Oral cancer kills  one person every hour. More than 8,000 Americans will die from oral cancer this year alone. Even more frightening, only 57% of people diagnosed with oral cancer live past 5 years.

Oral cancer has a higher death rate than most cancers because it is difficult to detect, often fails to produce noticeable symptoms and is, therefore, usually not discovered until it has metastasized to a secondary location, typically the lymph nodes. The lag time between infection and discovery allows oral cancer to invade other local structures, resulting in additional forms of cancer. The risk of producing primary tumors at a second site is 20 times higher for oral cancer patients.

Oral cancer causes squamous cell carcinomas in 90% of cases. There are several reasons oral cancer has begun to attack people under 40.

  • The war against smoking has made chewing smokeless tobacco popular with young men and women. Marketed as a safe alternative to smoking, it may reduce lung cancer but is a leading cause of oral and pancreatic cancer.
  • Human papilloma virus No. 16 is the leading cause of oral cancer. Sexually transmitted between partners, it is also a leading cause of cervical cancer.

Alternative cancer treatments developed by Issels Integrative Oncology offer new hope for people with oral cancer.

 

Practicing Sun Safety Critical for Skin Cancer Survivors

Melanoma Prevention
Melanoma Prevention

Surprising results of a new Yale University skin cancer study found that more than 25% of people who had survived malignant melanoma never use sunscreen. An even greater number of skin cancer survivors ignore advice to wear hats, long sleeves and slacks to protect their skin from additional sun damage and possible cancer reoccurrence. Perhaps most shocking was the admission by 2% of those surveyed that they had used a tanning bed after recovery from skin cancer.

On average, skin cancer survivors are more careful about protecting themselves from sun exposure than the general population. According to the study, 32% of cancer survivors always wear sunscreen, nearly twice as many as other adults. However, despite a risk of future melanoma that is 9 times greater than the norm, cancer survivors were as unlikely as their non-cancer peers take other preventive measures. According to the Skin Cancer Foundation, melanoma kills 9,000 Americans each year.

University of Texas cancer researcher Mary Tripp told USA Today that it is not unusual for skin cancer survivors to let down their guard:

“When someone is first diagnosed, they are practicing sun protection, but as the years go by, maybe they tend to fall back on their old habits. A lot of melanoma survivors have told me that it is very important for them to maintain a normal outdoor lifestyle.”

If you have survived malignant melanoma, there’s no need to give up the outdoor activities you love; but it is smart to take measures to protect yourself against the return of skin cancer. The Skin Cancer Foundation offers these guidelines:

  • Use a broad spectrum sunscreen that protects against both UVA and UVB rays.
  • For everyday use, sunscreens of SPF 15 should offer adequate protection. For extended outdoor activity, choose a water-resistant sunscreen of SPF 30 or higher.
  • For best protection, apply sunscreen 30 minutes before going outdoors and reapply every 2 hours.