Category Archives: Immuno-Oncology

Immuno-Oncology Heralded as a Cancer Game Changer

New Cancer Research Is In the News
Immuno- Oncology Discoveries

Finding a cure for cancer has been probably the top priority for the medical community for more than 50 years. In that arena, the development of immuno-oncology has been a game-changer, with experts referring to it as “a whole new era” of cancer treatment.

Clinical evidence

This view was strengthened by two studies presented at the recent annual meeting of the American Society for Clinical Oncology. Both involved nivolumab, an immunotherapy drug that has already been approved by the Food and Drug Administration for treating metastatic melanoma in patients for whom other medications have been unsuccessful.

In one study, nivolumab was paired with ipilimumab to reduce tumor size in patients with advanced melanoma by almost 60 percent. Melanoma is the most deadly form of skin cancer. The other study demonstrated that nivolumab reduced the chances of death from lung cancer by more than 40 percent.

The new standard of cancer treatment?

Results were so positive that they encouraged experts’ view that immunotherapy drugs could eventually replace chemotherapy as standard treatment for cancer. Prof. Roy Herbst, chief of medical oncology at Yale Cancer Center, believes that day could happen within the next five year.

Nivolumab is classified as a “checkpoint inhibitor,” meaning that it blocks the proteins that help cancer cells “hide” from the immune system. Using it in combination with other drugs gives immune cells a better chance to do their job.

Our center for immune-oncology has been successfully treating patients with individualized therapy protocols for nearly 15 years. Visit our website to hear and read testimonials in the words of our real-life cancer survivors.

Does the High Cost of Immunotherapy Mean You Won’t Get Treatment?

nurse feeds data of test tubes with blood for analysis into the database
Issels has options for immunotherapy treatment of cancer.

Immunotherapy for cancer that costs more than $1 million per patient per year? Issels® knows how frustrating coming to terms with the affordability of cancer treatment can be, and you’re not the only one taking notice. At the American Society of Clinical Oncology 2015 meeting, Dr. Leonard Saltz, MD of NYC’s Memorial Sloan Kettering Cancer Center brought the stark reality of this issue to light.

Unsustainable
Among the concerns addressed by Dr. Saltz was the need to establish cost controls for treatment, as there is an upper limit to how much society can afford to pay. Prices are not being based on the value of drugs, but what (the seller believes) the market will bear.

The trickle-down…
This year, the cost of a family insurance plan plus out-of-pocket expenses equates to approximately 50% the average U.S. household income. Continue this trend, and by 2028 it will be 100%.

How bad is it?
Saltz identified multiple therapies whose prices were in excess, limiting accessibility. The latest: pembrolizumab (Keytruda):

  • 2mg/kg (2014 standard dose) – $14,500 per month.
  • 10mg/kg (2015 proposed clinical trial dose) – $83,000 per month.

The astronomical out-of-pocket?
Saltz calculated for the average, 165 pound American patient, the drug would cost $1,009,944 per year for 26 doses. With a 20% Medicare copay, that’s a whopping $201,988 out-of-pocket for a single year of treatment! This stark reality is hoped to lead to a drastic changes in melanoma treatment, as many patients cannot afford medical insurance, least of all these copays and therapies.

Has playing the lotto become your backup plan for affording cancer treatment? Don’t give up hope. Contact Issels® and discover an array of cutting-edge immunotherapy  options today!

Why Is It Taking So Long to Find a Cure for Cancer?

Ideas on finding a cure for cancer.
Ideas on finding a cure for cancer.

At Issels®, we know that many of our readers wonder about research being done to find a cure for cancer. Many impatiently wait for progress as cancer leaves an indelible mark on anyone who has ever had cancer or known and/or loved someone who has had cancer.

Why is a cure taking so long?

Scientists are still trying to understand all of the complex processes that turn cells into the many types of cancers that exist.

How Does Cancer Form?

As Dr. Craig Thompson, CEO of the Memorial Sloan Kettering Cancer Center, pointed out in a recent article about this topic, family genetic inheritance, the formation site, immune system responses and cellular changes all factor into the complex puzzle that is cancer. We know that the last two items have the most influence:

  • The immune system isn’t perfect. Severe allergies and asthma are conditions that often happen when the immune system becomes confused about what it should or should not fight off to protect the body. Cancer is another example.
  • Many cells mutate into cancer because of natural aging changes we don’t yet completely understand. Sometimes there are errors during growth that repeat when new cells form. Lastly, cells can experience DNA damage from microorganisms, radiation, toxins and poor habits like smoking and tanning.

As Thompson noted, the key is to understand the “biology of cancer” and then use that knowledge to prevent it in those who don’t have it and create new treatments that precisely deal with causation in those who do.

At Issels® Immuno-Oncology, we have integrated many of the most recent precision techniques into our non-toxic, customized cancer treatment plans. For more information, contact us today.

Personalized Vaccines Are Recognized as the Future for Cancer Treatment

Cancer Vaccines
Cancer Vaccines

Vaccines save lives by utilizing the patient’s immune system to attack harmful cells. Much like flu vaccines prepare the person’s body to defend against pathogens, cancer prevention vaccines are given to people who do not have cancer to help their body identify and destroy infections known to lead to cancer. Treatment vaccines are for people who are already diagnosed with cancer. Issels® Integrative Immuno-Oncology uses non-toxic vaccine and cell therapy that is prepared from the patient’s own blood.

Washington University study

A recent study by scientists at Washington University found personalized cancer treatment was able to cure 90 percent of the mice used in the study that had advanced muscle cancer. This success prompted Alumni Professor of Pathology and Immunology for the university Robert Schreiber, PhD, who was senior author of the study, to say personalized cancer vaccines should be used to treat cancer in humans right away.

Immune-based treatments

Years of research on cancer genetics and how the immune system interacts with cancer have made new vaccines and treatments possible. Scientists agree immunotherapy is the best path to a cancer cure.

A personalized vaccine requires samples from the DNA of the individual’s tumor and healthy tissue. This aspect of creating an effective vaccine is difficult because cancer cells develop from the healthy cells of the person and are not easily recognized as harmful by the immune system. Despite the difficulties, experts agree that this type of integrative strategy is the best path to successfully treating cancer.

To find out more about the cutting edge non-toxic treatments and cell therapies utilized by Issels® Integrative Immuno-Oncology, contact us by phone or via our short online form.

Holiday Eating Tips for Cancer Patients

Holiday Eating
Holiday Eating

Just like there are some friends and family that you only see in person during the holidays, there are many beloved snacks, treats, and entrees that are holiday traditions. At Issels® Integrative Immuno-Oncology, we understand how a cancer diagnosis can disrupt every aspect of your life. But you can still celebrate that life and the holidays with loved ones. Keep these eating tips in mind as you enjoy the festivities.

  • Talk to your doctor about whether it is ok for you to drink alcohol. Complete abstinence is sometimes easier than moderation.
  • The same is true for many food items. Eat some healthy snacks before you leave your house to head toward a dinner or other gathering. You will find it much easier to avoid the temptation of decadent culinary creations.
  • Most get-togethers have a buffet. The American Cancer Society recommends you select items from the inside of the table and away from the edge. The area out of reach of small hands is less likely to have germs.
  • Be mindful of which items you can eat before you start filling your plate.
  • Take it slow and have small portions. This will prevent that lethargic feeling of being overfull.

Many holiday favorites will overwhelm a sensitive stomach. Try to avoid anything with heavy cream, gravy, or a mayonnaise base. You may have a weakened immune system and be more vulnerable to food-borne sickness. Avoid undercooked foods such as sushi, dishes with mayonnaise, and anything that may have raw eggs.

We continue to make progress in the fight against cancer. To stay informed on the latest cancer treatment breakthroughs and to get more health and nutrition tips, sign up for our e-newsletter.

Tips to Making Your December Holiday Memorable

Making The Most Of December
Making The Most Of December

Whether you celebrate Christmas, Hannukah or another holiday in the month of December, when you have cancer, this is a particularly precious time for you to enjoy with family and friends. Here at Issels®, we love this time of year, so it’s our pleasure to help you find wonderful ways to create beautiful life-long memories for your loved ones. Here are a few tips that will inspire you to start your holiday planning off right.

Tip #1: Take plenty of pictures – A picture is worth a thousand words, and the more pictures you have of your holiday celebrations, the better. When the celebrations are over, why not get together again and put together some photo books or scrapbooks depicting the joys of your holiday. If you really want to make a fun keepsake, you can have books professionally printed for everyone in your family.

Tip #2: Create new traditions – We all have our favorite traditions, but maybe it’s time to start some new ones this year. Perhaps you can add in some fun holiday games like a gift exchanging activity. Or, maybe you could plan a holiday cookie exchange. These traditions are a lot of fun, and they encourage everyone to get involved in a different way.

Tip #3: Consider getting involved in your community – There’s no better way to celebrate the holidays than giving back to your community. If you know a family who needs help buying presents, consider pooling your funds to surprise them. It is a season of giving, after all.

Here at Issels®, we specialize in not only improving the quality of life for our patients, but also in providing them with effective, alternative cancer treatments. If you’re interested in learning more, please contact us today.