Tag Archives: Advanced Cancer Research

Cancer Research, Uncategorized

University of California Creates a Cancer Consortium for Research

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Cancer Consortium Conference
Cancer Consortium Research Conference

There’s power in numbers, and the University of California is leveraging that concept to fight the battle against cancer. In September, the school announced that its five academic cancer centers are aligning to form a cancer research consortium.

Strength Through Teamwork

The partnership is made up of UC branches in Davis, Irvine, San Francisco, San Diego and Los Angeles. UC officials and researchers hope that the new consortium, believed to be the largest ever formed by a U.S. public university system, will enable larger clinical trials of cancer immunotherapy and other treatments across a wider spectrum.

The announcement has particular resonance in California, where cancer is on the verge of overtaking heart disease as the leading cause of death. It also has personal meaning for UC President Janet Napolitano, who was diagnosed with cancer in 2000 and again in 2016.

Cancer Research at the University of California

Currently, the five UC cancer centers treat 16 percent of cancer patients in California, with nearly half of them in late-stage cancer. In addition, the centers have administered more than 1,600 clinical trials over the last year, moving the top therapies along the road to FDA approval.

According to Paula Aspiazu of the American Cancer Society, their organization provides $23 million in funding to the UC system. Aspiazu pointed out that the consortium means each center can now draw data from a larger pool rather than only their own specific group.

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Alternative Cancer Treatment, Cancer Research, Cancer Treatment

Where Your Body Stores Fat May Predict Where You May Get Cancer

Where You Store Fat is Important
Where You Store Fat is Important

Excess weight has long been recognized as a risk factor for developing cancer. According to a recent study published in the British Journal of Cancer, where body fat is carried can be another indicator of obesity-related cancer risk.

Body Shape Can Increase Cancer Risk

The study, conducted by scientists at the International Agency for Research on Cancer (IARC) of the World Health Organization, were the first to compare adult body measurements in a standardized way. Data was obtained from 43,000 participants, 1,600 of whom had been diagnosed with an obesity-related cancer, and who were observed over an average of 12 years.

Results showed that an additional four inches added to the waistline equated to a 13 percent increase in the risk for obesity-related cancers. More significantly, adding three inches to the hips can boost the risk of bowel cancer by 15 percent.

How Can Obesity Cause Cancer?

Obesity is the second largest preventable cause of cancer behind smoking. Excess body fat alters the level of sex hormones, triggering an increase in production of insulin, ultimately leading to inflammation. All three factors have been linked to an increased risk of cancer.

Dr. Heinz Freisling, lead author of the study, explains that further investigation is needed to explore the connection between cancer and fat carried around the midsection, but results indicate that body shape should be considered along with body mass index (BMI) when evaluating cancer risk.

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Cancer Research, Immuno-Oncology, News

Cancer Research Embraces the Age of Super Computing

Supercomputers Catapult Speed of Research Ahead.
Supercomputers Catapult Speed of Research Ahead.

Can technology be the key that unlocks the secret to curing cancer? A report from the Cancer Moonshot Task Force confirmed the importance of supercomputers to research focusing on immunotherapy for cancer and other effective treatments.

HPC: A High-Tech Weapon Against Cancer

The Cancer Moonshot program originated in 2016 with the support of then-Vice President Joe Biden. At the time, Energy Secretary Ernie Monitz, a member of the task force, wrote about the role of high performance computing (HPC) in analyzing complex databases to identify patterns and other vital information.

How Cancer Researchers Use HPC

HPC systems such as the one at the Texas Advanced Computing Center use seven basic methodologies to understand cancer biology and possible treatments.

• Molecular simulations of protein and drug interactions help to create more effective treatments.

• Bioinformatics unravel the complexities of cancer genomes.

• Mathematical modeling is used to develop formulas that predict how cancer will behave.

• Quantum calculations help to refine radiation therapies.

• Computational treatment planning creates the pinpoint accuracy required to prevent radiation from damaging organs and healthy tissues.

• Computational trial design is used in immunotherapy for cancer to gauge the correct combination of dosages.

• Machine learning is how researchers develop algorithms and other statistical methods to analyze and interpret massive datasets.

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Cancer Research, Cancer Treatment, Immuno-Oncology, Immunotherapy, Immunotherapy for Cancer, News, Uncategorized

Family’s 1,200 Mile Bike Ride to Fund Cancer Research

Family Raises Money for Pediatric Cancer
Family Raises Money for Pediatric Cancer

Getting creative can always help with a cancer awareness campaign. For one family in Michigan, that meant climbing on a bicycle built for three and setting out on a six-week fundraising bike trek from a Detroit suburb to the Upper Peninsula of Michigan.

Karl and Eva Helminen have participated in many cancer fundraising efforts over the years, and they are also avid cyclists. As part of the Great Cycle Challenge USA program, they spent May 25 to July 5 on a bike with their 10-year-old son pedaling along, too. Their bulldog, Duchess, lent moral support and enjoyed restaurant leftovers along the way.

For the Helminens, the trip represented a special opportunity to help fundraise for childhood cancer treatment. As many families can relate, the Helminens have numerous family members and friends whose lives have been affected by cancer.

How Fundraising Events Help Cancer Treatment

Cancer awareness events can take many forms besides the typical walk or 5k run. Getting people talking and learning about cancer treatment and research projects is always the real goal.

The proceeds from cancer research events often get used to fund research to address difficult-to-treat types of cancer, including advanced stages, rare types, and cases that resist standard cancer therapeutic approaches.

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The fight against cancer still has a long path ahead, but awareness and research are making inroads. Contact Issels® to learn more about our non-toxic immunotherapy cancer treatment.

Alternative Cancer Treatment, Cancer Research, Immunotherapy, Immunotherapy for Cancer

Medical University of South Carolina’s Antibody Treatment Research Holds Promise

Immunotherapy for Cancer
Immunotherapy for Cancer using Antibody Treatment

Researchers continue to make strides in discovering new cancer immunotherapy methods that help doctors successfully target tumor cells. As revealed in a recently published report, a team of scientists at the Medical University of South Carolina (MUSC) have created a promising antibody-based therapy using a specific diagnostic marker known as GARP.

When Immune Cells Fail

Numerous studies have focused on TGF-beta, which is a protein used by regulatory T-cells (Tregs) to direct immune cells away from healthy cells. Malignant tumors get around this by releasing vast amounts of TGF-beta, essentially hijacking Tregs and causing them to suppress immune cell activity against the cancer cells.

GARP is the only known receptor that lets TGF-beta dock on cell surfaces. The MUSC team set out to determine whether GARP was the means by which tumor cells were able to harness TGF-beta.

Is GARP the Key to Activating Tregs?

After finding that GARP levels were higher in certain types of tumors, the team conducted a test in which they removed the GARP gene from mice with mammary tumors. As a result, the tumors grew more slowly and there was little metastasis to the lungs.

The MUSC team then used human GARP in mice to develop antibodies. Their hope is that in the future, cancer immunotherapy in conjunction with GARP antibodies will result in more effective treatment for breast cancer.

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Alternative Cancer Treatment, Cancer Research, Immunotherapy

Strategic T Cells Use May Be the Key to Effective Cancer Treatment

Advanced T Cells

T cells are the warriors of your immune system, but the ongoing battle against cancer can sap them of their disease-fighting powers. New research has discovered crucial information about these “exhausted” cells that can lead to more powerful immunotherapy for cancer.

The fundamental difference between active and exhausted T cells lies in their gene patterns. One example is PD-1, a protein expressed by exhausted T cells that prevents them from attacking both healthy and diseased cells. Checkpoint inhibitors can block PD-1, but their use is productive in only 25 percent of cases.

Can “Exhausted” T Cells Be Revived?

According to Nicholas Haining of Dana-Farber/Boston Children’s, senior author of the report posted in the journal Science, the goal of the study was to determine whether exhausted T cells are simply run-down versions of functional T cells or a separate type entirely. Regulatory regions of T cell genomes were mapped using chronically infected mice as subjects.

Results showed that the two types of cells are controlled by completely different wiring. In a separate study, use of checkpoint inhibitors gave the exhausted T cells a temporary boost, but did nothing to convert them to an active state.

The researchers hope this information will help to improve CAR T-cell therapy, in which T cells are removed from a patient and retrofitted to attack tumor cells. Complete mapping of regulatory regions will provide more precise targets for treatment.

Immunotherapy for Cancer Focuses on Tumors and Their Causes

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