Tag Archives: Fighting Cancer

Cancer Research, Immuno-Oncology, Immunotherapy, Uncategorized

Immuno-Oncology Heralded as a Cancer Game Changer

New Cancer Research Is In the News
Immuno- Oncology Discoveries

Finding a cure for cancer has been probably the top priority for the medical community for more than 50 years. In that arena, the development of immuno-oncology has been a game-changer, with experts referring to it as “a whole new era” of cancer treatment.

Clinical evidence

This view was strengthened by two studies presented at the recent annual meeting of the American Society for Clinical Oncology. Both involved nivolumab, an immunotherapy drug that has already been approved by the Food and Drug Administration for treating metastatic melanoma in patients for whom other medications have been unsuccessful.

In one study, nivolumab was paired with ipilimumab to reduce tumor size in patients with advanced melanoma by almost 60 percent. Melanoma is the most deadly form of skin cancer. The other study demonstrated that nivolumab reduced the chances of death from lung cancer by more than 40 percent.

The new standard of cancer treatment?

Results were so positive that they encouraged experts’ view that immunotherapy drugs could eventually replace chemotherapy as standard treatment for cancer. Prof. Roy Herbst, chief of medical oncology at Yale Cancer Center, believes that day could happen within the next five year.

Nivolumab is classified as a “checkpoint inhibitor,” meaning that it blocks the proteins that help cancer cells “hide” from the immune system. Using it in combination with other drugs gives immune cells a better chance to do their job.

Our center for immune-oncology has been successfully treating patients with individualized therapy protocols for nearly 15 years. Visit our website to hear and read testimonials in the words of our real-life cancer survivors.

Cancer Care Tips, Cancer Research, News, Uncategorized

T-Cells Take Center Stage in This Cancer Treatment Protocol

Cancer Gene
T- Cells Take Over

Being told you have cancer is hard to hear from your doctor. Fighting it is harder. Here at Issels®, we respect how difficult it is for you and we do anything we can to help you in your battle. Sometimes that means researching new treatments that can potentially save your life.

An article in Science Mag talks about one of these new treatments. Researchers have tested new cancer drugs that can help improve your immune system. In clinical trials of these drugs on patients with melanoma or lung cancer that were given a poor prognosis, these drugs were able to improve the prognosis in many of the participants. They were useless in patients with colon cancer with the exception of one man, who, after being treated in 2007, showed no sign of his metastatic tumors for several years.

This new drug is an antibody that blocks a receptor on the immune system’s T-cells called PD-1. When tumor cells activate the PD-1 receptor, they can hide T-cells. If this “checkpoint” is blocked by a PD-1 inhibitor, the T-cells can see the tumor cells and attack them. Researchers hypothesize that melanoma and lung cancer respond so well to PD-1 inhibitors because of their multiple mutations. The mutations may alter genes, causing small stretches of abnormal proteins. The immune system tends to see these as unfamiliar proteins, or antigens. The more of these “neoantigens” there are, the greater an attack from T-cells unleashed from a PD-1 inhibitor.

For more on this new research, go to Science Mag to read the full article.

If you have questions about immunotherapy treatments we use at Issels®, come visit our website today.

Alternative Cancer Treatment, Cancer Research, Immunotherapy, Uncategorized

The New Focus on Immunotherapy Drugs for Cancer Treatment

Hypothermia To Fight Cancer?
Focusing On Immunotherapy

No single cure-all cancer immunotherapy drug exists at this time. Instead, modern medicine offers several FDA approved single and combination drug options.

What do they do to the body?

As outlined in the Vox article “Is Cancer Immunotherapy Really a Miracle Cure?,” these treatments prompt a person’s immune system to destroy cancer cells when it will not do so on its own. Immuno-oncology research began as early as the 1890s when Dr. William Coley discovered he could shrink tumors in some patients by injecting bacteria directly into their tumors.

Immuno-oncology was mostly ignored for over a century because of more evident successes in surgical, radiation and chemo therapies. Yet, many researchers now believe it could be the key to curing cancers. Modern technologies have helped us better understand at the cellular level how cancer forms and spreads and how the body responds to different treatments.

Are there risks?

Every treatment available poses risks. Like chemotherapy, immunotherapy drugs have toxic side effects and can even cause adverse immune system reactions. Currently, these immunotherapy drugs do benefit many patients.

  • Their immune systems destroy targeted cancer cells and tumors.
  • They receive remission benefits for months longer than other treatments.
  • Some receive benefits for years longer.

Researchers are only beginning to understand how they can use modified viruses to prompt the immune system to work harder and more efficiently. As the article outlines, their biggest challenge is determining who will benefit and how to create new treatments for everyone else.

If you have exhausted all other options, our personalized Issels immunotherapy with non-toxic vaccine and cell therapies prepared from your own immune cells could turn everything around.

Alternative Cancer Treatment, Cancer Research, Uncategorized

Researchers Predict a Rise in Breast Cancer

Cancer Detection
Researchers Predict A Rise In Breast Cancer

At Issels® Integrative Immuno-Oncology, we pay close attention to research about cancer trends from around the world to help us improve our precision treatment methods.

According to research results announced in April by Dr. Philip Rosenberg, Ph.D of the National Cancer Institute’s Division of Cancer, Epidemiology and Genetics, Americans will see several new breast cancer trends by 2030.

Age Matters

Longer lifespans will result in more breast cancer cases:

  • Dr. Rosenberg predicts a more than 50 percent rise in breast cancer cases, including an estimated 11 percent increase in older women.
  • Women who live into their 70’s and early 80’s are at a higher risk of getting ER-positive in situ cancer (i.e. tumors caused by estrogen that are confined to the breasts).
  • ER-positive in situ cases will increase overall by an estimated 10 percent.

Hopeful News

Whether you have cancer or not, it’s important to remember the following:

  • These predictions were based on other predictions and assumptions — for example, that mammography will remain a major detection method.
  • The predictions were also based on incomplete and old data, including U.S. Census Bureau data, aggregate details about 500,000 patients diagnosed with cancer in the years up through 2010 and total cancer case numbers from 2011.
  • If the predictions are accurate, at least one group will deal less with certain breast cancers: a 10 percent decrease in overall cases for those ages 50 to 69.
  • Dr. Rosenberg also predicts an 8 percent decrease in the number of ER-negative in situ and invasive cancers that are difficult to treat.

To learn more about this study, cancer trends and/or our treatment options, contact our expert and caring Issels® staff today.

Alternative Cancer Treatment, Living with Cancer, Uncategorized

Immunotherapy: What It Is and How It Works to Fight Cancer

T Cells
Building Your Immune System

Immunotherapy represents a real breakthrough in cancer treatment. It activates the body’s own immune system so that it can identify and eliminate cancer cells. This approach to stage four cancer treatment has reduced the side effects of treatment and yielded impressive results.

Supercharge your Immune System

The great part about the human body is that is comes fully equipped with a protective system meant to fight outside invaders. The trick is to tap into that power and be able to target tumors and cell mutations. New clinical trials have been successful in achieving those goals. In fact, more and more immunotherapy drugs are being fast-tracked for FDA approval.

Fighting Sneaky Cancer Cells

Typically, the immune system has trouble recognizing cancer cells because they are very similar to normal cells. This allows cancer cells to sneak by the body’s natural defenses and spread. New drugs have been proven to boost the immune system and help it seek out and destroy mutated cells without putting you through radiation and chemotherapy treatments, which can come with a whole host of harmful side effects.

So far, immunotherapy drugs have been used to treat different types of blood and bone cancer, including Leukemia. The results have been so promising, that scientists feel confident that they will be able to tackle a wider range of cancers in the near future.

Issels® doctors’ expertise in integrating personalized vaccines into a comprehensive immunotherapy program has already benefited many patients. They are working hard to also advance new treatment methods. We believe in boosting the immune system and improving overall health and quality life during treatment. A comprehensive and personalized treatment plan is the best approach to beating cancer. Find out how we can help you in your fight against cancer today by asking about our immuno-oncology programs.

Alternative Cancer Treatment, Cancer Research, Uncategorized

Designer Cancer Therapies using Your Body to Fight Cancer

Alternative Lung Cancer Treatment
Fighting Cancer With Your Body

Dealing with the challenges of stage four cancer treatment can feel overwhelming and isolating, but there is good news. Doctors, scientists and researchers are working hard to make advances in cancer prevention and treatment and their efforts are paying off. The latest breakthrough involves creating a personalized vaccine that is designed to target each patient’s cancer.

Immunotherapy

Research shows that one of the best ways to fight cancer is to harness the power of the body’s own immune system. A personalized vaccine does this by telling your immune system to target a tumor. The result is a more focused treatment that isn’t as hard on the rest of your body as radiation or chemotherapy.

No Two Cancers are Alike

Every cancer patient experiences tumors behave differently. That is why a one-size-fits-all approach to stage four cancer treatment simply won’t be as effective as a more concentrated and personalized effort. Immunotherapy actually identifies the genes that are causing mutations and creates a vaccine that will specifically target those cells. This minimizes side effects and produces better results.

Developing Vaccines

A this stage in the process, scientists are still collecting data and trying to streamline all the various components involved in creating a vaccine. It takes time for them to produce a personalized vaccine. Cutting down on turnaround time could significantly increase the number of patients who are able to benefit from this specialized type of therapy.

Immunotherapy and personalized vaccines are just two components of an individualized treatment plan. At Issels®, we have many years of experience in preparing and administering personalized vaccines and also incorporate new methods as they are available. We take a comprehensive individualized approach to treatment because we know that cancer is a very complex systemic disease and every patient is different. Contact us today to find out more.