Tag Archives: Lung Cancer Treatment

Cancer Research, Cancer Treatment, Immuno-Oncology, Immunotherapy, News, Uncategorized

Why Some Lung Cancers Do Not Respond to Some Types of Immunotherapy Treatment

Why Some Lung Cancers Do Not Respond to Some Types of Immunotherapy Treatment
Why Some Lung Cancers Do Not Respond to Some Types of Immunotherapy Treatment

Despite the drop in smoking rates, lung cancer remains the second most common form of the disease in the United States. Scientists are hopeful that a recent discovery will aid the development of more effective immunotherapy for lung cancer.

A Roadblock in Lung Cancer Treatment

The immune system is the body’s first line of defense against foreign invaders. Immunotherapy is a form of cancer treatment that boosts the ability of the immune system to seek out and destroy cancer cells.

Current immunotherapy for lung cancer includes a drug that shuts down a protein on the surface of tumor cells. The protein, called PD-L1, latches on to T cells and prevents them from attacking.

Unfortunately, many lung cancer patients didn’t respond positively to this treatment. Scientists realized they needed to learn more about the “immune compartment of lung tumors,” which involves the relationship between the cancer cells and the tumor microenvironment.

Scientists Make a Breakthrough

A research team in Switzerland studied mice with a form of lung cancer similar to that in humans. They found that a type of immune cell known as Gr1+ neutrophils actually triggers a cycle in the microenvironment that promotes the growth of tumor cells.

Team leader Prof. Etienne Meylan explained that neutrophils are an essential part of the immune response, so removing them is not the answer. Future research will focus on how the neutrophils operate and how immunotherapy for lung cancer can work around them.

Issels®: The Leader in Effective Immunotherapy

For decades, we have been successful treating patients with immunotherapy for lung cancer and other forms of the disease. Contact us for more information.

Cancer Treatment, Stage Four Cancer Treatment

What’s the Deadliest Cancer of All? Lung Cancer. Find out Why.

Find Out Why Lung Cancer is the Deadliest Cancer
Find Out Why Lung Cancer is the Deadliest Cancer

While advances in cancer treatment have improved survival rates for many of its forms, lung cancer continues to be the deadliest type of the disease. Despite alarming statistics, lung cancer remains a lower priority for medical researchers.

Lung Cancer Accounts for One-Quarter of Cancer Deaths

Approximately 14 percent of new cancer cases are lung cancer, but it makes up a disproportionate 26 percent of cancer deaths. According to the Lung Cancer Alliance, that averages out to 427 deaths from lung cancer each day in America, which is more than the number of deaths from breast, prostate and colon cancer combined.

Despite these numbers, less funds are allocated to lung cancer research than the other three leading forms. In 2016, the National Institute of Health spent only $1,500 per lung cancer death as opposed to $19,250 for breast cancer, $9,400 for prostate cancer and $5,800 for colon cancer.

Does Lung Cancer Merit Less Attention?

Smoking is the leading cause of lung cancer, but nearly 18 percent of cases are found in non-smokers. Four years ago, former educator Ginny Hicks found herself in the latter group when she was diagnosed with Stage 4 non-small cell lung cancer.

As Hicks undergoes treatment in a clinical trial of an immunotherapy drug, she has become an advocate for lung cancer research and education. According to Hicks, lung cancer has a stigma attached due to a common perception that smokers bring the disease on themselves.

Non-Toxic Cancer Treatment at Issels®

We have helped patients with Stage 4 lung cancer and other metastatic tumors achieve long-term remission with personally tailored immunotherapy programs. Contact us for more information.

Cancer Research, Cancer Treatment, Uncategorized

Smoking May Actually Prime Lung Cells for Cancer

Cancer Research News
Cancer Research News

The link between cigarette smoking and increased risk of lung cancer is well-established. Recent studies are giving researchers more insight into the causes of the connection as well as possible methods of treatment.

What Causes Genetic Abnormalities?

Gene behavior is driven by DNA code, but it can also be affected by other external factors. These events, such as those brought on by exposure to cigarette smoke, are known as epigenetic changes.

Researchers at Johns Hopkins Kimmel Cancer Center in Baltimore grew human bronchial cells, the same type that line airways in the lungs, and bathed them daily with a liquid form of cigarette smoke. This procedure went on for 15 months, making it the equivalent of smoking one to two packs of cigarettes a day for 20 to 30 years.

How Smoking “Primes” Cells for DNA Damage

After only 10 days, the smoke-exposed cells sustained more DNA damage than unexposed cells. Over the next three months, the exposed cells showed a significant increase in EZH2, which is a hormone that silences genes.

EZH2 is also a precursor to methylation, in which tiny methyl groups are added to the start of a gene’s DNA code. As a result, tumor suppression genes are silenced and thereby unable to prevent the uncontrolled cell growth of cancer. Smokers who quit show a lower level of methylation, which can decrease their risk of cancer.

Integrative Cancer Immunotherapy Treatment at Issels®

Our cancer immunotherapy programs incorporate gene-targeted therapies based on a patient’s individual needs. Contact us for more information about our decades of success initiating long-term remission with our innovative cancer immunotherapy treatments.

 

Alternative Cancer Treatment, Cancer Treatment, Living with Cancer, Stage Four Cancer Treatment, Uncategorized

More Medications Focus on Immunotherapy to Combat Lung Cancer

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Join Us in the Fight Against Lung Cancer
Join Us in the Fight Against Lung Cancer

As immunotherapy becomes an increasingly significant factor in cancer treatment, major pharmaceutical companies are scrambling to get their own piece of the pie. One of the minor players has seemingly vaulted ahead of the competition by targeting a niche segment of the market that had been largely overlooked.

AstraZeneca’s Second Chance for Success

AstraZeneca made a bold but risky move by going all-in on their pair of immuno-oncology drugs (IO) designed to treat lung cancer. The combo turned out to be a major failure, which seemed to spell doom for the company.

Surprisingly, trial results presented at a recent European cancer conference seem to indicate a turnaround for Astra’s fortunes. Imfinzi, the lead drug in their IO duo, has proven to be more successful in treating patients with mid-stage lung cancer.

Blazing New Trails in Cancer Treatment

Most pharmaceutical companies concentrate on late-stage lung cancer, which represents a greater share of the market. Focusing on the under-served mid-stage lung cancer segment gives Astra the chance for modest but substantial sales growth outside the shadow of competitors such as industry leader Merck & Co.

According to experts, pharmaceutical industries are so fearful of losing business that they tend to stay in the same lane as their competitors. The experts believe that a company has a greater chance of success as a pioneer in an area with little activity.

Issels®: Leading the Way in Personalized Cancer Treatment

While immunotherapy is a seemingly new development in cancer treatment, we have been using cancer vaccines and other non-toxic protocols for decades. Contact us for more information about our individually tailored treatment programs.