Category Archives: Immunotherapy for Cancer

Immunotherapy for Cancer, Uncategorized

Some Cancer Risk Factors Are Within Your Control

Cancer is driven by numerous and complex risk factors, making concepts related to calculating its risk a frequent subject of debate. Adding to this debate is a Johns Hopkins study looking at randomly mutating cells, specifically how they play a predominant role in cancer development. What does this say about your cancer risk? Issels® wants to help you put this new information in perspective.

Cancer and car accidents: They have a lot in common…

  • Trip length
    Comparing getting cancer to getting into a car accident, the length of your trip – your lifespan – increases your risk. The longer you live, the more the odds increase of your body randomly mutating cells, making this a significant risk factor – attributable to two-thirds of your total cancer risk in fact.
  • Road conditions
    Just as rain or snow can increase your risk of an accident, so too can conditions in your body and in your environment increase your risk of cancer.
  • Mechanical issues
    Bad brakes or worn tires can be seen as a metaphor for genetic factors, such as inherited mutations.

Reading the accident report
Despite this research, it can’t be stressed enough no single factor causes cancer. Two-thirds of car accidents are not related solely to trip length, but to a combination of road conditions, mechanical issues, and the like. For each “accident,” the major contributing factor will vary.

Accident prevention
Due to the large combination of risk factors, there are many opportunities for prevention, including addressing radiator issues (smoking), regular maintenance (early diagnostics and detection), and more.

Cancer spinning out of control? Contact Issels® today.

Immunotherapy for Cancer, Uncategorized

Understanding How Cancer is Diagnosed

Healthcare professionals agree that early diagnosis improves the chances for successful cancer treatment. If you experience symptoms or a screening test calls for a closer look, these are the tests most frequently used to make a diagnosis of cancer.

1. Blood chemistry test

Our organs routinely release enzymes, electrolytes and other substances into the bloodstream. Abnormally high or low levels could be a sign that kidneys, liver or other organs are not working properly, which could be due to cancer.

2. Complete blood count (CBC)

A CBC, which is a detailed analysis of the bloodstream, is often conducted during routine physicals. Factors include the number of red and white blood cells and platelets, as well as the amount of hemoglobin, which is the protein that carries oxygen. CBCs are particularly useful in diagnosing cancers in the blood stream, known as leukemia.

3. Liquid biopsy

Liquid biopsies are used to find out if cancer cells or DNA from tumor cells are present in the blood. This test can be also part of determining appropriate cancer treatment and follow-ups to see if the treatment is working.

4. CT scans and MRIs

Both CT scans and MRIs involve taking detailed pictures of your body’s interior. A CT scan uses an x-ray machine, while an MRI involves a magnet and radio waves.

5. Biopsy

A biopsy is most often used to diagnose cancer, but it can also help diagnose other health problems, such as cirrhosis. When lesions, lumps or other tissue abnormalities are detected, a doctor will remove a sample so the cells can be studied more closely.

Cancer Treatment for Advanced Cases

At Issels®, our non-toxic programs have helped to achieve long-term remission in patients, even if they are already in Stage IV. Visit our website to read and hear their testimonials.

Immunotherapy for Cancer, Uncategorized

Immunotherapy: “The New Hope” for Cancer Patients

After years of research, scientists are still unable to pinpoint the causes and predictors of cancer with absolute certainty. The good news is that immunotherapy for cancer now offers hope for patients who previously had few options.

An Immunotherapy Success Story

One such patient was Tish Vigna. Four years ago she was diagnosed with stage 3 cancer in her left lung, despite being a physically fit non-smoker. She underwent a course of chemotherapy, radiation and surgery only to discover that the cancer had spread to her right lung.

Tish’s oncologist suggested that she enter a clinical trial of immunotherapy for cancer at Princess Margaret Hospital in Toronto. After months of treatment, doctors found that the tumors had shrunk in half and there has been no subsequent growth.

How Does Immunotherapy Work?

Immunotherapy is a process of boosting the ability of your own immune system to fight cancer cells naturally. These treatments generally fall within two categories:

  • With adoptive T-cell therapy, doctors extract the attacking T-cells from a patient’s tumor to increase their numbers. The cells are then re-entered into the patient’s system where they are now better equipped for battle.
  • The immune system has a braking mechanism that prevents it from going into overdrive. Checkpoint inhibitors disable these brakes so the T-cells can attack cancer cells with full force.

Issels®: Leading the Way with Immunotherapy

While immunotherapy for cancer has been making a big splash in the medical community recently, Issels® has been successfully using these personally tailored treatments for decades. Contact us today for more information about our immunotherapy programs such as cancer vaccines and NK cells.

Immunotherapy for Cancer, Uncategorized

What to Look for If You Think Your or a Loved One Has Cancer

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Early detection can be a huge advantage for successful cancer treatment. Do you think you or a loved one may be suffering from cancer? Here are some of the primary signs and symptoms to watch for.

Difference Between Signs and Symptoms

While they may seem like the same thing, there is an important difference between signs and symptoms.

*Signs are measurable conditions, such as a fever, that can be observed by another person.

*Symptoms are detectable only by the person who is actually experiencing them. Pain and fatigue fall into this category.

Keep in mind that many signs and symptoms may be temporary and caused by something other than cancer. Be sure to consult a doctor if these conditions become exacerbated or don’t go away over time.

Possible Signs and Symptoms of Cancer

*Fatigue or tiredness that is not relieved by rest

*Significant weight loss or gain (10+ pounds) with no apparent cause

*Eating and digestive problems, including lack of appetite, stomach pain, nausea and vomiting or constipation, diarrhea or other changes in bowel habits

*Swelling, thickening or lumps in the breast or any part of the body

*Sudden unexplained pain that becomes more serious or continues to linger

*Changes in skin features, such as a new mole or altered appearance in an existing one, a sore that refuses to heal or a yellowish color in skin or eyes

*Chronic coughing and hoarseness

*Bleeding or bruising that appears suddenly without reason

*Pain or blood in the urine, or increase or decrease in frequency of urination

*Fever or night sweats

*Headaches

*Vision or hearing problems

Issels®: The Leader in Personalized Cancer Treatment

With our state-of-the-art immunotherapy cancer treatment, even many patients with advanced cancer have achieved long-term remission. Contact us to see how Issels® can help you or your loved one.

Immunotherapy for Cancer, Uncategorized

Should Genetic Testing For Cancer Be Expanded?

Lifestyle choices, such as smoking and poor diet, can affect your chances of developing cancer, but some people carry a high risk for the disease in their DNA. The medical community is currently debating whether widespread genetic testing will do more harm than good.

Would Lower-Cost Tests Mean Greater Accessibility?

BRCA-related cancers occur when the genes that produce tumor-preventing proteins mutate to the point where they lose that ability. These genetic changes result in higher risk of breast, prostate, ovarian and pancreatic cancers as well as melanoma.

Testing can normally run into thousands of dollars, making it generally available only via insurance coverage to individuals with a strong family history of cancer. But biotech companies have come up with viable tests that cost less than $500.

When Knowledge is a Dangerous Thing

Experts such as Mary-Claire King, the award-winning geneticist who originally identified the BRCA1 gene, think that the new testing methods should be considered routine like Pap smears and mammograms. Others are not convinced.

Why is caution needed with the new genetic testing?

• Genetics is not a cut-and-dried specialty, and not all variations can be interpreted correctly.

• Some companies sell these tests directly to consumers without clear information about limitations and risks.

At this point, knowing your family history is still the best indicator of a possible genetic link to cancer.

Genomic Testing and Immunotherapy for Cancer

At Issels®, our immunotherapy for cancer treatments are personally developed to allow for individual factors such as genetic predisposition and lifestyle. Visit our website to learn more about our state-of-the-art protocols.

Immunotherapy for Cancer, Uncategorized

Researchers Learn How to Make Large Quantities of Immune Cells for Cancer Vaccines

Immunotherapy for cancer is all about boosting a patient’s natural defense systems. Thanks to a breakthrough by researchers at Mount Sinai Medical Center in NYC, scientists are now able to generate certain immune cells outside the body.

The Role of Dendritic Cells

Dendritic cells serve as an early warning system for the immune system. These cells give the signal to “arm” the system with disease-specific weapons. A major plus is that dendritic cells can attack all forms of cancer while causing few side effects.

Unfortunately, the down side is that dendritic cells are normally in short supply. Extracting them from patients to use in immunotherapy for cancer proves to be a difficult, time-consuming and expensive process.

Dendritic Cells and Immunotherapy

The research team at Mount Sinai discovered a way to grow human dendritic cells in vitro. According to Nina Bhardwaj, MD, PhD, Director of Immunotherapy at the Tisch Cancer Institute at Mount Sinai’s Icahn School of Medicine, the ability to generate these cells on a large scale opens the door for extensive studies of potential applications in highly refined cancer vaccines.

In another promising development, the study also provided insight into notch signaling. This biological pathway plays a major role in generating cDC1, which is the optimum dendritic cell for cancer vaccines. The team discovered that some current treatments disrupt notch signaling, which interferes with the immune system’s efficiency in fighting tumors.

Benefits of this study are twofold. In addition to applications for cancer treatments, the information may help prevent organ transplant rejection, which is another function of the immune system.

Longtime Leaders in Immunotherapy for Cancer

Issels® has long been in the forefront with dendritic cell therapy. Our non-toxic treatments are created to meet each patient’s individual needs. Contact us for more information.