Category Archives: News

Alternative Cancer Treatment, Cancer Research, Cancer Treatment, News, Uncategorized

Research Studies Now Under Way to Starve Cancer Tumors

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Research Studies Now Under Way to Starve Cancer Tumors
Research Studies Now Under Way to Starve Cancer Tumors

According to a popular old wives’ tale, you should starve a cold and feed a fever. Scientists working on immunotherapy for cancer are taking that advice a step further as they develop a new treatment that “starves” tumors to death.

Cutting Off Cancer’s Fuel Source

Glutamine is an amino acid found throughout the body, with the largest concentrations in blood and bone. While glutamine plays a major role in cellular synthesis of proteins, it also provides fuel for the rapid cell division of many types of cancer.

A research team at Vanderbilt University in Nashville began exploring the idea of blocking glutamine from cancer cells as a possible form of treatment. They focused on ASCT2, a protein that transports glutamine to cancer cells as well as other parts of the body.

The scientists created an ASCT2 inhibitor called V-9302. In testing on both mice and cancer cells developed in vitro, V-9302 was able to stop tumor growth by increasing oxidative stress on cancer cells, leaving them to eventually die off.

Using PET Imaging to Trace Tumors

As the team noted in their report, the next step is to find a way to determine how effective the inhibitors are in restricting glutamine access. The researchers suggested using positron emission tomagraphy (PET) scans to spot increases in glutamine metabolic rates.

Individually Created Immunotherapy for Cancer at Issels®

Not all cancer patients respond to treatment the same way. That’s why our immunotherapy for cancer programs are designed to address each patient’s unique case. Contact us to learn more about Issels® and our track record of helping patients achieve long-term remission.

Cancer Research, News, Uncategorized

Common Acid Reflux Drug May Increase Stomach Cancer Risks

Common Acid Reflux Drug Make Increase Stomach Cancer Risks
Common Acid Reflux Drug Make Increase Stomach Cancer Risks

Acid reflux is a relatively common condition that affects a number of people worldwide. Evidence from recent studies suggests that one of the more widely-used acid reflux treatments may increase the risk of stomach cancer.

H. Pylori and Stomach Cancer

Around the globe, stomach cancer is the fifth most common cancer causing the third highest number of cancer-related deaths. H. pylori, a bacterium found in two-thirds of the world’s population, is a major cause of ulcers and a significant risk for stomach cancer.

A 2016 review revealed an association between long-term use of proton pump inhibitors (PPI), a frequently prescribed treatment for acid reflux, and increased risk of cancer. Scientists remained uncertain because the review failed to distinguish between H. pylori and H. pylori-negative participants.

Can Acid Reflux Treatment Increase Stomach Cancer Risk?

In 2017, researchers at the University of Hong Kong set out to find some clarity on the issue. The team separated the study group into PPI users and those using another acid reflux drug known as H2 blockers.

Nearly 64,000 participants began with a seven-day course of triple therapy, which involves use of a PPI with two antibiotics to eradicate H. pylori. Results showed that, even in the absence of H. pylori, PPI usage more than doubled risk of stomach cancer while usage of H2 blockers demonstrated no increased risk.

Immunotherapy for Cancer: A Non-Toxic, Integrative Program

At Issels®, our individually created immunotherapy for cancer treatments have helped patients with stomach cancer and other therapy-resistant forms. Contact us for more information about the legacy of our namesake, Dr. Josef M. Issels, and our non-toxic immunotherapy programs.

Breast Cancer, Cancer Research, News, Uncategorized

MSK1 Protein Research May Answer Why Some Breast Cancer Stays Dormant

MSK1 Protein Research May Answer Why Some Breast Cancer Stays Dormant
MSK1 Protein Research May Answer Why Some Breast Cancer Stays Dormant

Scientists have long been puzzled by the process of metastasis in breast cancer and what causes the cells to lie dormant. A recent study revealed valuable information that can pay off with more effective breast cancer treatment.

Understanding Latency in Breast Cancer Metastases

Researchers at the Institute for Research in Biomedicine (IRB) in Barcelona set out to study estrogen-positive (ER+) breast tumors that feature long periods of asymptomatic latency. This type accounts for 80 percent of breast cancer cases.

The Barcelona team identified a protein kinase called MSK1 as the primary regulator of dormant metastases. After examining clinical samples from patients, the researchers determined that ER+ breast cancer tumors that don’t express MSK1 tend to suffer earlier relapse, while those that do express MSK1 experience later metastases.

Breakthrough in Breast Cancer Treatment

Head researcher Roger Gormis explained that little was previously known about why breast cancer metastasis time varies from one patient to another. Study results also showed that suppressing MSK1 causes faster-growing cancer cells that have a greater chance of metastasizing.

Benefits of the study are two-fold:

– Doctors may be better able to identify patients who are more likely to relapse and adjust treatment protocol.

– Scientists may be able to develop a treatment that mimics the role of MSK1, thereby keeping metastasis dormant for as long as possible.

Effective Late-Stage Cancer Treatment at Issels®

Our non-toxic, personally tailored immunotherapy programs have effectively treated patients with late-stage and therapy resistant cancer of all forms, including breast, lung and colorectal. Contact us to learn more about why Issels® is the leader in state-of-the-art immunotherapy treatments.

Cancer Research, News, Uncategorized

New Blood Test Created by Johns Hopkins to Screen for Eight Cancers

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New Blood Test Created by Johns Hopkins to Screen for Eight Cancers
New Blood Test Created by Johns Hopkins to Screen for Eight Cancers

Early detection often makes the difference in successful cancer treatment. Thanks to a newly developed blood test, doctors will soon be able to screen for eight of the more common types of cancer.

Focusing on Early Stage Cancer Detection

CancerSEEK was developed by a team of scientists at Johns Hopkins Kimmel Cancer Center. It screens for cancers of the ovaries, liver, stomach, pancreas, colorectum, lung and breast. Collectively, these types are responsible for more than 60 percent of cancer deaths in the United States.

Based on the idea that circulating tumor DNA mutations can be specific cancer markers, the researchers set out to study several hundred genes and 40 protein markers. They finally ended up with segments of 16 genes and eight proteins, with the small mutation panel minimizing the possibility of false-positive results.

According to Nickolas Papadopoulos, senior author of the study, the team was inspired by the concept of using combinations of drugs for cancer treatment. When the test was administered to 1,005 patients with non-metastatic cancer, its median overall sensitivity to cancer was 70 percent with only seven false-positives.

The Future of CancerSEEK

Researchers are proceeding to larger studies of CancerSEEK. They project that once the test is approved for use the cost will be less than $500, and primary care providers will be able to administer the test with other routine blood work.

Cancer Treatment for Therapy-Resistant Tumors

Our non-toxic immunotherapy programs have been successful with advanced cases of all types of cancer, including breast, lung and colorectal. Contact us to learn more about state-of-the-art cancer treatments at Issels®.

Cancer Research, Cancer Treatment, Immuno-Oncology, News, Uncategorized

Protein Blocking May Play a New Role in New Testicular Cancer Treatment

Protein Blocking May Play a New Role in New Testicular Cancer Treatment
Protein Blocking May Play a New Role in New Testicular Cancer Treatment

What options does a patient have when traditional forms of cancer treatment fail? In the case of testicular cancer, scientists found a new combination of treatments that may provide added hope.

Overcoming Resistance to Cancer Treatment

Testicular germ cell tumors are a form of cancer found most commonly in younger men. A research team at the Institute of Cancer Research in London, encouraged by earlier work at the facility, examined the function of a certain type of protein in the development of testicular cancer.

The team focused specifically on insulin growth factor receptor-1. They discovered that IGF1R, as the protein is also called, was more active in some testicular cancer cells as opposed to normal tissue. Using chemical inhibitors, the researchers were able to deplete the supply of IGF1R or curtail its activity, thereby reducing cell growth.

In addition, blocking IGF1R activity in previously drug-resistant cells made them more receptive to platinum-based chemotherapy. The team is hopeful that the two treatments, used in tandem, will be more successful in killing testicular cancer cells.

What Does the Future Hold?

Receptor tyrosine kinases, the class of proteins that includes IGF1R, are linked to cell growth and division in several other types of cancer. Clinical trials have tested the use of IGF1R in hopes that they may have positive results in other applications.

Effective Cancer Treatment for Therapy-Resistant Tumors

For decades, Issels® has been helping patients with advanced and therapy-resistant cancer achieve long-term remission. Contact us to learn how we are continuing the legacy of our founder, Dr. Josef M. Issels, who was a pioneer in the field of immunotherapy for cancer.

Alternative Cancer Treatment, Cancer Research, Cancer Treatment, Cancer Vaccine, Immuno-Oncology, Immunotherapy, Immunotherapy for Cancer, News, Uncategorized

Adoptive Cell Transfer a Natural Immunotherapy for Cancer

Adoptive Cell Transfer a Natural Immunotherapy for Cancer
Adoptive Cell Transfer a Natural Immunotherapy for Cancer09

Scientists are excited about immunotherapy for cancer because it supplements a patient’s own natural defenses of the immune system. Thanks to a recent study, researchers have made a discovery that could lead to more effective immunotherapy treatments.

What Is Adoptive Cell Transfer?

Adoptive cell transfer, one of the primary forms of immunotherapy for cancer, involves extracting a patient’s T-cells, which are a form of white blood cells that attack foreign invaders in the system. After engineering the T-cells to target the specific proteins in cancer cells, they are injected back into the patient.

While adoptive cell transfer has been successful in treating blood and bone marrow cancers, it’s been less effective with solid tumors. A team from The Scripps Research Institute and the University of California, San Diego set out to find a better way to program the T-cells.

Unleashing the Power of T-Cells

The researchers zeroed in on a protein known as Runx3, which appeared to specifically direct T-cells to solid tumors. During testing on animal models, it was found that overexpression of Runx3 led to delayed tumor growth and longer life.

Matthew Pipkin of Scripps said that Runx3 works on chromosomes within T-cells, enabling them to focus on killing tumor cells. Pipkin was hopeful that their discovery would pave the way for improving the effectiveness of adoptive cell transfer on solid tumors.

Issels®: The Leader in Immunotherapy for Cancer

Our proprietary immunobiologic core protocols are specifically designed to meet each patient’s individual needs. Contact us to learn more about our record of helping patients achieve and sustain long-term remission.